【作者】 平静；

【导师】 王均宁；

【作者基本信息】 山东中医药大学 ， 方剂学， 2013， 博士

【摘要】 目的搜集历代含附子的方剂，基于毒、效关系角度，探讨附子不同主治病证相关用药配伍规律，为临床趋利避害合理运用附子提供理论依据。方法文献学与统计学方法相结合。以中医文献学的方法梳理历代本草方书对附子的记载，利用频数描述和非参数统计的方法，总结附子方的基本运用特点，包括方源、给药途径、剂型、单方复方、是否含酒、附子的炮制和用量，利用关联规则方法挖掘附子不同主治病证常见药物组合，探究其配伍规律。结果第一，系统梳理并建立了含附子的方剂信息数据库，包括方剂3915首，涉及693种中药，1676频次；336种病证，926频次。第二，总结了不同历史时期方书所载附子方中毒效相关因素的应用规律，包括给药途径、炮制、剂型、单方复方、是否用酒。第三，着重统计了历代附子方中附子的药量变化，并分析了不同主治病证、不同剂型的药量特点。第四，挖掘并总结出附子方不同主治病证的常用药物组合及配伍规律。结论第一，与附子毒效相关的因素包括给药途径、炮制、剂型、单方复方、是否含酒、药量、主治病证，以上诸方面不同的运用特点，对增效控毒有影响。第二，各个历史时期附子的药量总体上差异不大，且多数处于《中国药典》规定的安全有效范围内。附子治疗疮疡病、痹病、风邪证、寒痛证时用量偏大，且附子大量使用时剂型多为汤剂。第三，在药量差异不大时，复方配伍环境下的合理配伍用药，是影响控毒增效的主要因素，应注重随证、随病而用药。更多还原

【Abstract】 Objective：This paper collects ancient prescriptions containing Fuzi and makes acomprehensive study on the using rules of Fuzi with different syndromes based on thetoxicity and efficiency correlation. Drawing on the advantages and avoid disadvantages,this paper provide theoretical basis for proper use of Fuzi in clinic.Method： This paper mainly adopts literature method combine with statisticalmethod.The author combs through the records of Fuzi from medical literatures of pastdynasties.By using the method of frequency distribution and nonparametric statistics,itsummarizes the general features of Fuzi including origin,administrationroute,formulation,single or complex prescription, whether containing alcohol,preparationand dosage of Fuzi in the prescription, then it uses association rules to find out thecommon drug combination in different syndromes,and thus makes a thorough inquiry oncompatibility law of Fuzi.Result：Firstly,it established the data base of prescriptions and indications of Fuziincluding3915prescriptions,693Chinese drugs and336syndromes for a total of1676drugs and926syndromes.Secondly, summarized the using rules of Fuzi prescription andrelated factors of toxicity and efficiency in different historical periods.Thirdly, mainlycalculate the dosage of Fuzi and analyse the features with different syndromes anddifferent formulation.Finally,the paper sums up the common drug combination andcorresponding compatibility law of different syndrome with Fuzi prescription. Conclusion：First of all,the factors related toxicity and efficiency of Fuzi include theroute of administration,formulation,single or complex prescription,whether containingalcohol,dosage and the main indications.All the aspects above have great influence ontoxicity control and efficiency increase.Second, the dosage of Fuzi generally have minordifference in each historical period in China,and the majority is safe and effective withinthe scope of Chinese Pharmacopoeia.Large dose are applied on carbuncles andulcers,Bi-syndrome and pathogenic wind syndrome, the dosage form of Fuzi with big doseis always decoction.Third,if the difference of dosage is not that big, compoundcompatibility could be an great influence on toxicity control and efficiency increase.Thedoctor should modify the drugs according to the syndromes or diseases.更多还原