【作者】 安佰海；

【导师】 吉中强；

【作者基本信息】 山东中医药大学 ， 中医内科学（专业学位）， 2013， 博士

【摘要】 目的：作为教育部新世纪优秀人才支持计划（No.NECT-07-0522）高血压中医辨证研究的一项重要基础性工作，建立原发性高血压肝肾阴虚证的宏观量化诊断标准，探索中医辨证诊断规范化研究的思路与方法。方法：在文献调研、临床流行病学调查、专家咨询的基础上，建立原发性高血压肝肾阴虚证宏观诊断量表，并从信度、效度、反应度等方面对量表进行考评。以该量表为测量工具，在流行病学调查基础上，经过指标赋权，建立原发性高血压肝肾阴虚证的宏观量化诊断模型和标准。最后对该标准进行临床诊断性试验。结果：编制了原发性高血压肝肾阴虚证宏观诊断量表，综合测评表明该量表信度、效度及反应度良好。在此基础上建立了原发性高血压肝肾阴虚证量化诊断标准，诊断阈值为197。临床诊断性试验结果显示，该标准具有较高的灵敏度、特异度、准确度及阳性似然比。结论：通过文献研究、临床流行病学调查、量表研制、统计分析及临床验证建立的规范的原发性高血压肝肾阴虚证宏观量化诊断标准具有良好的可行性、准确性和实用价值。本研究成果将为高血压肝肾阴虚证的进一步深入研究和证候疗效评价提供标准化尺度，为其它病证的诊断研究提供可供借鉴的研究思路与方法。更多还原

【Abstract】 Objective：TCM syndrome of hypertension is the important basic work of the NewCentury excellent Talent of Education Ministry support program (No.NECT-07-0522). Toestablish the macroscopic quantitative diagnostic standard of liver-kidney yin deficiencysyndrome of essential hypertension and explore a new method of standardization of TCMsyndrome differentiation.Methods： Control study of modern literature and clinical retrospective study ondistribution rule of TCM syndromes of essential hypertension were respectively carriedfirst. The macroscopic diagnostic scale of liver-kidney yin deficiency of essentialhypertension was constituted according to literature research, clinical epidemiologicalinvestigation and expert consultation.Then，the re1iability, validity and responsiveness ofthe scale were evaluated. The macroscopic quantitative diagnostic model and standard ofliver-kidney yin deficiency of essential hypertension were established by determining itemweights according to epidemiological investigation. Clinical diagnostic experiments wereperformed on the standard finally.Results： The diagnostic scale of liver-kidney yin deficiency of essentialhypertension was compiled and proved to have good re1iability, validity andresponsiveness. The quantitative diagnostic standard of liver-kidney yin deficiency ofessential hypertension was established, whose lowest critical value was197. Clinicaldiagnostic experiment showed that it had high sensitivity，specificity，accuracy andpositive likelihood ratio.Conclusion： The diagnostic scale of liver-kidney yin deficiency of essentialhypertension established through literature research，clinical epidemiological investigation, scale compilation，statistical analysis and clinical verification has good feasibility, accuracyand clinical practical value. The results of this research will offer standardized scale forfurther research of liver-kidney yin deficiency of essential hypertension, and methods forstandardization study on other syndromes.更多还原