【作者】 考希良；

【导师】 张伟；

【作者基本信息】 山东中医药大学 ， 中西医结合临床（专业学位）， 2013， 博士

【摘要】 目的：明确中医“肺痰”的内涵，探讨肺痰在临床上尤其是呼吸系统疾病中的特殊致病意义。运用临床研究资料来验证肺痰理论的正确性，以期为临床治疗提供科学的理论依据，同时发展中医理论的肺痰学说。方法：运用文献研究、现代研究和临床研究相结合的方法。文献研究方面参阅古文献阐述肺痰学说相关理论；现代研究方面从不同学科角度阐述肺痰与现代研究之间的联系；临床研究方面观察化痰中药方剂对慢性阻塞性肺疾病（COPD）急性加重期患者的疗效。结果：第一，系统论述了肺痰学说的相关内容，总结出肺痰的实质其实既是病理产物同时又是致病因素的双重内涵。第二，详细探讨了肺痰与现代研究之间的关系。第三，临床研究证实化痰中药方剂对COPD急性加重期有确切疗效。结论：第一，肺痰是客观存在的，肺痰学说是成立的。肺痰既是病理产物同时又是致病因素。肺痰分为有形之肺痰和无形之肺痰。肺痰有独特致病特点。第二，肺痰病理复杂，与呼吸道慢性炎症、细胞生物学、免疫异常、血液流变学、血液生化改变、微循环、自由基、黏蛋白、脂类代谢异常密切相关。第三，临床研究发现，化痰中药方剂具有抗菌、抗病毒、止咳、平喘、祛痰、抗过敏、改善肺动脉高压、提高免疫力和抗氧化等作用，对COPD急性加重期患者有较好疗效。更多还原

【Abstract】 Objective: Clear the connotation of "lung phlegm", and discuss the specialpathogenic significance about the lung sputum in clinic especially in respiratory systemdiseases. In view of the clinical research data, we has verified the theory of the lungsputum, which can provide the scientific theory basis to the clinical treatment, and at thesame time, we could develop the theory of lung phlegm in traditional Chinese medicine.Methods: The method combined with the literature research, modern research andclinical research method. In the literature research, we refer to the documents to expoundthe lung phlegm theory; in the modern research, we expound the connection of the lungsputum and modern research from different perspectives; in the clinical research, weobserve the efficacy of traditional Chinese medicine in the acute aggravating period ofchronic obstructive pulmonary disease（COPD）.Results: First, elaborate the theory of lung sputum. Second, discuss the relationshipbetween the lung sputum and modern research in detail. Third, the clinical researchconfirmed that Chinese medical phlegm had definite effect for acute COPD.Conclusion: First, the lung phlegm is the objective existence, and the lung sputumtheories are established. The Lung sputum is divided into the tangible and intangiblesputum, and the lung sputum have distinctive characteristics of the disease. Second, thepathologic of lung sputum is complex and related closely to the chronic inflammation, cellbiology, immune abnormalities, blood rheology and blood biochemical changes,microcirculation, free radicals, sticky protein, and lipid metabolism disorder. Third, theclinical study found that the phlegm proprietary Chinese medicine has the effects ofantibacterial, antiviral, relieving a cough, eliminating the phlegm, relieving asthma, allergy,improving pulmonary hypertension, enhancing immunity and antioxidant, and it has goodcurative effect for COPD patients with acute aggravating period.更多还原