【作者】 马丽虹；

【导师】 孟令军；

【作者基本信息】 山东中医药大学 ， 中医基础理论， 2005， 硕士

【摘要】 目的:定性总结活血化瘀法在缺血性中风急性期的应用情况,定量比较不同活血化瘀方药治疗该病的临床疗效。方法:严格按照循证医学系统评价方法,全面收集运用活血化瘀方药治疗缺血性中风急性期的临床研究文献,并按照文献选择标准进行筛选:采用Jadad评分标准评价纳入研究质量;采集相关数据进行同质性检验、Meta-分析、漏斗图分析及敏感性分析等。结果:共检索到相关文献1148篇,经三次筛选,纳入合格研究54项,涉及活血化瘀方药12类,其中53项为低质量研究,1项为高质量研究。临床总有效率Meta-分析结果既有统计学意义又有临床意义的活血化瘀方药共5种,经敏感性分析显示Meta-分析结果稳定可靠的有3种,其中总有效率的合并相对危险度最大的是三七提取物(三七总皂甙),其它依次为补阳还五汤及其提取物、脉络宁。结论:本系统评价认为三七提取物是治疗缺血性中风急性期的首选活血化瘀药物,其次推荐应用脉络宁注射液、补阳还五汤及其提取物,并提示在治疗过程中注意药物量效关系、剂型-疗效关系及配用补气药物可能会提高临床疗效。更多还原

【Abstract】 Objective: Summarize the complexion of Activating Blood Circulation Herbs for acute ischaemic stroke in summary; Compare the clinical curative effect of different Activating Blood Circulation Herbs, search the best Activating Blood Circulation Herb for acute ischaemic stroke. Method: Strictly according to follow the method of systematic review, collect completely the clinic study of TCM for acute ischaemic stroke, choose the eligibility studies and appraise their quality, collect the data of the studies, make Meta-analyse, funnel plots and tests for heterogeneity. Result: Collect 1148 related articles, through sieving three times, bring into 54 studies, 53 among those itemses are low quality studies, 1 the item is a high quantity to study. According to Meta-analys and sensitivity analysis, 3 kinds of Activating Blood Circulation Herbs(BuYangHuanWu-tang, Mailuoning injector, sanqi injector) are availability for acute ischaemic stroke. Thereinto sanqi of relative risk is the most.RR for fatality rate of Meta-analys has not statistics meaning. Conclusion:Passing the system review, the sanqi injector is first commended for acute ischaemic stroke, BuYangHuanWu-tang and Mailuoning injector also are commended.更多还原