【作者】 黄颖；

【导师】 李红梅；

【作者基本信息】 黑龙江中医药大学 ， 中医妇科学（专业学位）， 2015， 硕士

【摘要】 研究目的：本课题采用中药三联疗法治疗阴虚夹湿型萎缩性阴道炎,以观察其临床疗效,并对此法进行疗效评价,为本法在临床上应用及推广提供理论依据。研究方法：本课题将符合纳入标准的96例萎缩性阴道炎患者,随机分成三组,即A组32例(三联组,即口服+阴道冲洗+阴道纳药),B组32例(口服+阴道冲洗),C组32例(口服+阴道纳药)。通过治疗前后三组患者中医证候、阴部体征、阴道分泌物PH值、清洁度检查、阴道脱落细胞及复发率的比较,观察其疗效。研究结果：1.三组患者治疗后总疗效情况：A、B、C组总有效率分别为93.75%、80.00%、87.10%,经统计学分析,P>0.05,无统计学意义,三组总有效率无显著性差异；A、B、C三组愈显率分别为81.25%、53.33%、58.06%,经统计学分析,A组分别与B、C组比较,P<0.05,有统计学意义,表明A组愈显率明显优于B、C两组,B、C两组比较,P>0.05,无显著性差异2.中医证候、阴部体征积分情况：组内比较,A、B、C三组治疗后中医证候积分及阴部体征积分与疗前比较,均明显下降,P<0.05,说明三组治疗方案皆能有效地改善中医证候和阴部体征；治疗后组间比较,A组中医证候及阴部体征总积分明显低于B、C组,P<0.05,说明A组较B、C组疗效更为显著；B、C两组相比较,P>0.05,无显著性差异3.阴道分泌物PH值、清洁度积分情况：组内比较,A、B、C三组治疗后阴道PH值、清洁度积分与疗前相比,均明显下降,P<0.05,说明三组治疗方案皆能有效地改善阴道环境,降低PH值和清洁度；治疗后组间比较,A组积分和明显低于B、C组,P<0.05,说明A组较B、C组疗效更为显著；B、C两组相比较,P>0.05,无显著性差异。4.阴道脱落细胞情况：组内比较,A、B、C三组治疗后MI均“右移”,且MV值均有升高,P<0.05,说明三组治疗方案皆能促进阴道上皮的增生,提高阴道雌激素水平；疗后MV值组间比较,A、B组相比,A组明显优于B组,P<0.01,差异极为显著；A、C组相比,A组优于C组,P<0.05,差异显著；B、C组相比,C组优于B组,P<0.05,差异显著。即A组最好,次之为C组,再者为B组。5.治疗后随访复发率情况：A组分别与B、C组比较,均有P<0.05,差异性显著,说明A组复发率明显低于B、C组；B、C两组比较,P>0.05,无显著性差异。研究结论：根据研究表明,中药汤剂口服联合中药阴道冲洗及纯中药制剂保妇康栓纳药法治疗阴虚夹湿型萎缩性阴道炎疗效确切,在改善中医证候,阴部体征,阴道分泌物PH值、清洁度及阴道脱落细胞分布变化各项指标方面有明显的优势。本方案具有愈显率高,复发率低的优点,在临床治疗萎缩性阴道炎具有一定的价值更多还原

【Abstract】 Research purposes:This subject adopts the traditional Chinese medicine triple therapy in treatment of yin clip wet atrophic vaginitis, to observe the clinical curative effect, and curative effect evaluation of the method, as to provide theoretical basis for this law in the clinical application and promotion.Research methods:The issue met the inclusion criteria 96 cases of atrophic vaginitis were randomly divided into three groups, namely a group of 32 patients (triple therapy group, oral medicine + vaginal douche + encolpism),32 cases of group B (oral medicine + vaginal douche), group C 32 patients (oral medicine + encolpism). By comparing the three groups of patients before and after treatment syndromes, genital symptoms, vaginal secretions PH value, cleanliness inspection, vaginal exfoliated cells and compare the recurrence rate observed its efficacy.Research results:1. The total curative effect after treatment in patients with three groups: A, B, C group total effective rate were 93.75%,80.00%,87.10%, after statistics analysis, P> 0.05, no statistical significance, three groups total effective rate have no significant difference; A, B, C three groups markedly effective rate were 81.25%,53.33%,58.06%, after statistics analysis, group A compared with group B and C, respectively, P<0.05, there is statistical significance, showed markedly effective rate of group A is better than two groups of B, C. Group B compared with group C, P>0.05, no significant difference.2. TCM syndrome, vaginal signs of integration:comparison group, A, B, C three groups after treatment of TCM syndrome integral and vaginal signs integral compared with before treatment,were significantly decreased, P<0.05 suggesting that three groups of treatment can effectively improve the syndromes and vaginal signs; Comparison between treatment group, group A of syndromes and vaginal signs total score was lower than that in group B, C P<0.05, suggesting that group A with B and C group results more significantly; group B compared with group C, P> 0.05, no significant difference.3. The vaginal PH condition, cleanliness:the comparison within groups, A, B. C three groups after treatment of vaginal PH, cleanliness of integral compared with before treatment, were significantly decreased, P<0.05, suggesting that three groups of treatment can effectively improve the vaginal environment, reduce the PH value and cleanliness; Comparison between groups after treatment, group A set of integral was lower than that in group B. C, P<0.05, suggesting that the effect of group A was more significant than that of group B and C; group B compared with group C, P> 0.05, no significant difference.4. Vaginal exfoliated cells:comparison within groups, A, B, C three groups after treatment MI were "right" and MV values were increased, P <0.05, suggesting that three groups all can promote the treatment of vaginal epithelial hyperplasia, improve the level of vaginal estrogen; MV value comparison between groups after treatment, compared to group A, B, group A was better than group B, P<0.01, and extremely significant difference; gruop A compared with group C, group A is better than that of group C, P<0.05, significant difference; Compared with group B, C, group C is better than that of group B, P<0.05, significant difference. The group A is best, second in group C, and the final B group.5. Recurrence rate after treatment:group A compared with group B and C respectively, both P<0.05, the difference significant, suggesting group A recurrence rate was lower than that in group B, C; group B compared with group C, P>0.05, no significant difference.Research conclusions:According to the research shows that Chinese medicine medicinal broth of oral combined Chinese medicine douching and BaoFuKang Shuan encolpism method to treat yin clip wet atrophic vaginitis is effective in improving the TCM syndrome, vaginal signs, vaginal PH, cleanliness and vaginal exfoliated cells distribution change each index has obvious advantage. This scheme has the markedly effective rate is high, the recurrence rate is low, the advantages of atrophic vaginitis has certain value in clinical treatment.更多还原