【摘要】 目的　观察高甘油三酯血症对血管内皮功能的影响。方法　对 30名高甘油三酯血症患者和 30名正常人采用高分辨超声技术检测血流介导和硝酸甘油介导的肱动脉舒张功能 ,并测定血浆内皮素和血脂。结果　 (1)高甘油三酯血症患者血流介导的肱动脉舒张较正常组明显减弱 [分别为(2 7± 2 0 ) %和 (15 0± 8 0 ) % ,P <0 0 0 1],而两组对硝酸甘油的血管舒张反应无显著性差异 [分别为 (15 0± 5 0 ) %和 (16 8± 9 0 ) % ,P >0 0 5 ]。 (2 )高甘油三酯血症患者血浆内皮素水平 [(10 6 2 2± 19 16 ) μg/L]显著高于正常组 [(72 37± 14 0 6 ) μg/L](P <0 0 0 1)。 结论　高甘油三酯血症患者内皮依赖性血管舒张功能明显受损。血管内皮功能失调可能是高甘油三酯血症致动脉粥样硬化的一个重要机制。更多还原

【Abstract】 Objective To investigate the effects of hypertriglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow- and nitroglycerin-induced dilation of the brachial artery was measured in 30 hypertriglyceridemic patients and 30 healthy subjects (control group). Both serum lipid and plasma endothelin (ET) levels were determined at the same time. Results (1) In patients with hypertriglyceridemia, flow-induced vasodilatation was much reduced compared with that in the control subjects [(2.7 ±2.0)% vs (15.0±8.0)%, P <0.001]. However, vasodilatation in response to nitroglycerin was similar in both groups [(15.0±5.0)% vs (16.8±9.0)%, P >0.05]. (2) Plasma ET level in the hypertriglyceridemic group [(106.22±19.16)μg/L] was significantly higher than that in the control group [(72.37±14.06)μg/L]( P <0.001).Conclusions Endothelium-dependent vasodilatation is impaired in patients with hypertriglyceridemia. The endothelial dysfunction may contribute to the atherogenic actions of hypertriglyceridemia.更多还原