【摘要】 近年来，关于含硼药物，尤其是硼酸类药物的研究逐渐增多。含硼药物代表了药物化学家在研发领域开拓的一类新成果，这类药物在抗炎、抗菌、抗肿瘤等方面正扮演着愈发重要的角色。目前，全球已有5个含硼药物获批上市，正处于临床试验阶段的含硼药物也不在少数，同时近几年在研新药的不断出现，极大地扩展了硼在药物研发领域的应用。本文通过介绍硼元素的特性，并对处于各个研究阶段的代表性含硼药物的适应证，与靶点的结合机制，以及它们进入临床试验后的进展进行综述，以期为含硼药物的进一步研究提供参考。更多还原

【Abstract】 In recent years, the research on boron-containing drugs, especially boric acid drugs, has been increasing gradually. Boron-containing drugs, which have been a new area of research for pharmaceutical chemists in the development of new drugs, play an increasingly important anti-inflammatory, antibacterial, and anti-tumor role. At present, five boron-containing drugs have been approved, many are under clinical trials, and more are under investigation around the world, which has greatly expanded the application of boron in the research of new drugs. This paper introduces the characteristics of boron, and reviews the indications of representative boron-containing drugs in various research stages, their binding mechanisms with targets, and their progress after entering clinical trials, aiming to provide reference for further research on boron-containing drugs.更多还原