【摘要】 目的 探讨中药松弛膏联合跑台运动康复干预方案对关节挛缩大鼠关节纤维化中ROM、IL-6、IL-17和TGF-β1表达的影响。方法 44只Wistar大鼠，随机取8只大鼠为正常对照组(NC组),其余36只大鼠建立关节挛缩模型。将32只造模成功的大鼠分为模型对照组(MC组)、中药松弛膏干预组(SC组)、跑台运动康复干预组(RE组)、中药松弛膏+跑台运动康复干预组(SR组),每组8只。MC组不进行任何干预；SC组给予药物涂抹按摩；RE组给予跑台训练；SR组给予跑台训练后再进行药物涂抹按摩，干预均为每天1次，每周6 d。于干预前、干预42 d后测量所有大鼠ROM;干预42 d后采用ELISA法检测大鼠IL-6、IL-17含量及TGF-β1含量。结果 干预前模型组大鼠ROM与NC组相比显著降低(P<0.05);干预42 d后，与MC组ROM相比，SR组ROM和SC组ROM显著增加，差异均具有统计学意义(P<0.05)。干预后与MC组比，SC组、RE组及SR组IL-6、IL-17含量显著降低，其中SR组显著低于SC组及RE组(P<0.05);SR组TGF-β1含量均较MC组、SC组及RE组显著降低(P<0.05)。结论 中药松弛膏联合跑台运动康复干预能协同改善关节挛缩大鼠的关节活动度，减轻炎症因子释放，减少与纤维化有关的TGF-β1的分泌，从而改善关节挛缩大鼠关节纤维化的程度。更多还原

【Abstract】 Objective To investigate the effects of songchi ointment combined with running platform exercise rehabilitation on range of motion(ROM) and expression of interleukin(IL)-6, IL-17 and transforming growth factor-β1(TGF-β1) in articular fibrosis of rats with articular contracture. Methods Among 44 Wistar rats, eight rats were randomly selected as the normal control group(NC group), and the other 36 rats were established joint contracture model. A total of 32 rats were divided into the model control group(MC group), songchi ointment intervention group(SC group), running platform exercise intervention group(RE group), and songchi ointment + running platform exercise intervention group(SR group) by the random number table method, with eight rats in each group. The MC group did not subjected to any intervention; the SC group was subjected to a drug smear massage, the RE group was subjected to running platform exercise; the SR group was subjected to running platform exercise, followed by drug smear massage, intervention was once a day, 6 days a week. Before intervention and after 42 days of intervention, ROM was measured in all rats. After 42 days of intervention, IL-6, IL-17 and TGF-β1 contents of the rats were measured by ELISA.Results Before intervention, ROM of the model group was significantly lower than that of the NC group(P < 0.05). After 42 days of intervention, compared with the MC group, ROM of SR and SC groups was significantly increased, the differences were statistically significant(P<0.05). After intervention, compared with the MC group, IL-6 and IL-17 contents in SC, RE, and SR groups were significantly decreased, and those in the SR group was significantly lower than those in the SC and RE groups(P < 0.05). TGF-β1 content in the SR group was significantly lower than that in the MC, SC, and RE groups(P < 0.05). Conclusions Songchi ointment combined with running platform exercise rehabilitation improves joint ROM, reduces the release of proinflammatory factors, and reduces the secretion of TGF-β1 related to fibrosis in rats with joint contracture to improve the degree of joint fibrosis.更多还原