【摘要】 目的分析糖皮质激素辅助治疗在儿童肺炎支原体感染性大叶性肺炎临床治疗中的价值。方法选取2012年4月-2016年4月在该院接受治疗的肺炎支原体感染性大叶性肺炎患儿142例,根据随机分配原则,将142例患儿分成对照组与观察组,每组71例。对照组采用常规治疗方法,观察组在常规治疗基础上应用糖皮质激素辅助治疗。两组患儿治疗后比较分析临床疗效和不良反应发生情况。结果治疗后,观察组治疗总有效率为97.2%,明显高于对照组的60.6%(P<0.05)。观察组患儿退热时间、咳嗽缓解时间和肺部X片检查恢复正常的时间明显短于对照组(P<0.05)。治疗后,观察组患儿炎性指标白细胞介素-6(IL-6)、白细胞介素-2(IL-2)、血沉(ESR)和C反应蛋白(CRP)的改善程度明显优于对照组(P<0.05)。观察组治疗中不良反应发生情况较少,与对照组比较,差异无统计学意义(P>0.05)。结论糖皮质激素辅助在儿童肺炎支原体感染性大叶性肺炎的临床治疗中效果好,不良反应发生少。更多还原

【Abstract】 Objective To analyze the clinical value of glucocorticoid hormone in assisted treatment of children with lobar pneumonia caused by Mycoplasma pneumoniae. Methods A total of 142 cases of children with lobar pneumonia caused by Mycoplasma pneumoniae were selected from the hospital from April 2012 to April 2016,then they were randomly divided into control group and observation group,71 cases in each group. The children in control group received conventional treatment,and the children in observation group were treated with glucocorticoid hormone adjuvant therapy on the basis of routine treatment. The clinical effects and incidence rate of adverse reactions in the two groups were compared and analyzed after treatment. Results After treatment,the total effective rate in observation group was 97. 2%,which was statistically significantly higher than that in control group( 60. 6%)( P<0. 05). The defervesce time,cough relieving time,and the recovery time of pulmonary X scan in observation group was statistically significantly shorter than that in control group( P<0. 05). After treatment,the improvement degrees of inflammatory indexes,such as interleukin-6( IL-6),interleukin-2( IL-2),erythrocyte sedimentation rate( ESR),and C-reactive protein( CRP) in observation group were statistically significantly better than those in control group( P<0. 05). The incidence rate of adverse reactions was low in observation group,and there was no statistically significant difference between the two groups( P>0. 05). Conclusion The clinical effect of glucocorticoid hormone in assisted treatment of children with lobar pneumonia caused by Mycoplasma pneumoniae is good,and the incidence rate of adverse reactions is low.更多还原