【摘要】 目的探究补气益肾活血法联合介入治疗早中期股骨头坏死的临床效果。方法选取山东省聊城市中医医院2018年6月—2020年6月收治的早中期股骨头坏死患者120例,采用随机数字表法将其分为对照组和观察组,每组各60例。对照组给予选择性血管药物介入治疗,观察组在对照组的基础上实施补气益肾活血法治疗,两组均连续治疗1个月。比较两组临床疗效及不良反应发生情况。比较两组治疗前后中医症状积分、骨代谢指标,以及随访3个月后的髋关节功能。结果观察组的总有效率、髋关节功能优良率均高于对照组,差异均有统计学意义(均P <0.05)。治疗后,两组中医证候积分、Ⅰ型胶原交联羧基末端肽(CTX-Ⅰ)、抗酒石酸盐酸性磷酸酶(TRAP)均低于治疗前,血清骨钙素(BGP)及Ⅰ型胶原氨基端延长肽(PⅠNP)均高于治疗前,且观察组中医证候积分、CTX-Ⅰ、TRAP均低于对照组,BGP及PⅠNP均高于对照组,差异均有统计学意义(均P <0.05)。两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论补气益肾活血法联合介入治疗早中期股骨头坏死能改善患者的中医证候,促进骨代谢指标改善,帮助缓解髋关节功能,且不会增加不良反应,安全性较高。更多还原

【Abstract】 Objective To explore the clinical effect of Buqi Yishen Huoxue method combined with interventional therapy on early and middle stage femoral head necrosis. Methods A total of 120 patients with early and middle stage femoral head necrosis admitted to Liaocheng Traditional Chinese Medicine Hospital, Shandong Province, from June 2018 to June 2020 were selected. They were divided into control group and observation group by random number table method,with 60 cases in each group. The control group was treated with selective vascular drug interventional therapy, and the observation group was treated with Buqi Yishen Huoxue method on the basis of control group. Both groups were treated continuously for one month. Clinical efficacy and the incidence of adverse reactions were compared between two groups.Traditional Chinese medicine(TCM) syndrome scores, bone metabolism indexes before and after treatment, and hip joint function after three months follow-up were compared between the two groups. Results The total effective rate and the excellent and good rate of hip joint function in the observation group were higher than those in the control group,with statistical significance(all P < 0.05). After treatment, TCM syndrome score, Ⅰ type collagen cross-linked carboxy-terminal peptide(CTX-Ⅰ) and tartrate-resistant acid phosphatase(TRAP) in two groups were lower than those before treatment, serum osteocalcin(BGP) and Ⅰ type collagen amino-terminal elongation peptide(PⅠNP) were higher than those before treatment, and TCM syndrome score, CTX-Ⅰ and TRAP in the observation group were lower than those in the control group, BGP and PⅠNP were higher than those in the control group, and the differences were statistically significant(all P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P > 0.05). Conclusion Buqi Yishen Huoxue method combined with interventional therapy on early and middle stage femoral head necrosis can improve the TCM syndrome, promote the improvement of bone metabolism indexes, and help alleviate hip function without increasing adverse reactions, with high safety.更多还原