【摘要】 目的 探讨脑小血管病(CSVD)患者认知功能障碍发生情况及其与血清3-硝基酪氨酸(3-NT)、同型半胱氨酸(Hcy)、血小板与淋巴细胞比值(PLR)、成纤维细胞生长因子23(FGF23)水平的相关性。方法 选取2019年2月至2022年2月邯郸市第一医院神内二科收治的206例CSVD患者。采用蒙特利尔评估量表(MoCA)对所有患者认知功能进行评价，按照分值分为认知功能障碍组和认知功能正常组。比较两组患者MoCA相关项目评分、血清3-NT、Hcy、PLR、FGF23水平及其相关性。结果 ≥26分的患者有60例，纳为认知功能正常组；<26分的患者有146例，纳为认知功能障碍组。与认知功能正常组比较，认知功能障碍组视空间及执行能力、命名、注意力、语言、抽象思维、延迟记忆、定向力、MoCA评分总分较低，血清3-NT、Hcy、PLR、FGF23水平较高，差异均有统计学意义(P<0.05)；经Pearson相关系数分析，血清3-NT、Hcy、PLR、FGF23水平分别与MoCA各项评分及总分均呈负相关，差异均有统计学意义(P<0.05)。结论 血清3-NT、Hcy、PLR、FGF23水平分别与MoCA各项评分及总分呈负相关，临床上可通过检测上述指标水平评估患者的认知功能，进而为CSVD的治疗提供参考。更多还原

【Abstract】 Objective To investigate the occurrence of cognitive dysfunction in patients with cerebral small vessel disease(CSVD)and its relationship with serum 3-nitrotyrosine(3-NT),homocysteine(Hcy),platelet to lymphocyte ratio( PLR)and fibroblast growth factor 23(FGF23)levels. Methods From February 2019 to February 2022,206 patients with CSVD were selected from the Second Department of Neurology of Handan First Hospital. The Montreal Assessment Scale(MoCA) was used to evaluate the cognitive function of all patients,and they were divided into the cognitive dysfunction group and the normal cognitive function group according to the scores. The MoCA-related item scores,serum 3-NT,Hcy,PLR,FGF23 levels and their correlations were compared between the two groups. Results There were 60 patients with a score of ≥26 and 146 patients with a score of <26. Compared with the normal cognitive function group,the visual space and executive ability,naming,attention,language,abstract thinking,delayed memory,orientation,MoCA score of the cognitive dysfunction group were lower,and the serum 3-NT,Hcy,PLR,FGF23 levels were higher,and the differences were statistically significant(P<0.05). The Pearson correlation coefficient analysis showed that the serum levels of 3-NT,Hcy,PLR,and FGF23 were negatively correlated with the MoCA scores and total scores,and the difference were statistically significant(P<0.05). Conclusion Serum 3-NT,Hcy,PLR,and FGF23 levels were negatively correlated with Mo CA scores and the total score.Clinically,the cognitive function of patients can be evaluated by detecting the levels of the above indicators,and then provide reference for the treatment of CSVD.更多还原