【摘要】 作为一种重要的化工原料和氘代中间体，氘代甲醇（CD₃OD）被广泛应用于核磁共振试剂、氘代药物中间体、光电材料改性，但其在CO-CO₂体系中的催化合成效率仍有待提高。文章通过热力学计算CO-CO₂加D₂制备氘代甲醇反应条件对反应物平衡转化率的影响，并采用CuO/ZnO/Al₂O₃催化剂，设计正交实验探索合成氘代甲醇的最佳反应条件。以氘代甲醇时空产率为指标，实验获得的最优反应条件为：反应温度240℃,反应压强5 MPa;n（D₂）/n（CO+CO₂）为3,n（CO）/n（CO₂）为1。更多还原

【Abstract】 As an important chemical raw material and deuterated intermediate, deuterated methanol（CD₃OD） has been widely used in nuclear magnetic resonance reagents, deuterated drug intermediates and photoelectric materials modification, but its catalytic synthesis efficiency in CO-CO₂ system still needs to be improved.Herein, the effect of reaction conditions on the equilibrium conversion rate during the process of preparation of deuterated methanol from CO-CO₂ and D₂ is calculatedally.In the case of CuO/ZnO/Al₂O₃ catalyst, the optimal reaction conditions for the synthesis of deuterated methanol is investigated by orthogonal experiment.Taking the space-time yield of deuterated methanol as the index, the optimal reaction conditions obtained in the experiment are as follows: the reaction temperature is 240 ℃,the reaction pressure is 5 MPa; the molar ratio of D₂/（CO+CO₂） is 3,and the molar ratio of CO/CO₂ is 1.更多还原