【摘要】 目的 了解北京市MSM对HIV非职业暴露后预防（nPEP）知识的知晓情况，以及使用nPEP的相关因素。方法 于2021年12月至2022年1月，在北京市通过MSM手机交友软件招募年龄≥18岁、最近1年与男性发生过肛交性行为的MSM为调查对象。采用自行设计的网络问卷进行横断面调查，收集调查对象的基本信息、性行为情况、nPEP知识知晓以及nPEP的使用情况，分析nPEP使用的相关因素。结果 回收有效问卷1 105份，调查对象18～29岁占52.8%;nPEP知识知晓的比例为59.3%;nPEP使用率为14.5%。多因素回归分析结果显示，与近12个月未进行过HIV检测者相比，检测次数为4次及以上者使用nPEP的可能性更高（OR=5.031,95%CI:2.461～10.285）；与近6个月无HIV阳性性伴者相比，有阳性性伴者使用过nPEP的可能性更高（OR=2.207,95%CI:1.023～4.760）；与近6个月未发生过商业性性行为者相比，发生过商业性性行为者使用过nPEP的可能性更高（OR=3.305,95%CI:1.611～6.780）；而与近6个月发生肛交时不能坚持使用安全套者相比，能够坚持使用安全套者使用过nPEP的可能性更低（OR=0.568,95%CI:0.383～0.842）。结论 北京市使用某MSM交友软件者nPEP的使用知识的掌握情况仍处在较低水平，而具有高危行为者nPEP使用的可能性更高。更多还原

【Abstract】 Objective To understand the knowledge and related factors on HIV nonoccupational post-exposure prophylaxis among men who have sex with men in Beijing 2021. Methods From December 2021 to January 2022, a mobile dating app for MSM was applied to recruit research subjects who were ≥18 years, had anal sex with men in the past year in MSM groups in Beijing. We conducted a cross-sectional survey through a self designed network questionnaire to collect social demographics, behavioral characteristics, knowledge of nPEP use and use of nPEP. Multiple logistic regression was used to analyze the related factors of nPEP use. Results 1105 valid questionnaires were collected. Among them, 52.8% of the survey respondents were 18-29 years old, 59.3% understood the nPEP knowledge, and 14.5% had utilized nPEP. In addition, multivariate regression analysis showed that compared with MSM who had not been tested for HIV in recent 12 months, those who had been tested four times were more likely to have used nPEP(OR=5.031,95%CI:2.461-10.285). Compared with those who did not have HIV-positive sexual partner in the last six months, those with an HIV-positive sexual partner were more likely to have used nPEP(OR=2.207, 95%CI: 1.023-4.760). Compared with those who did not have commercial sex in the last six months, those who had commercial sex were more likely to have used n PEP(OR=3.305, 95%CI: 1.611-6.780). Compared with those who could not consistently use condoms during anal intercourse in the last six months, those who could consistently use condoms were less likely to have used n PEP(OR=0.568,95%CI:0.383-0.842). Conclusions The mastery of knowledge about the use of n PEP among the MSM population in Beijing is still at a low level, while those with high-risk behaviors are more likely to use n PEP.更多还原