【摘要】 目的：探讨红景天甙在心肺复苏后心功能不全中的保护作用。方法：18只健康SD大鼠（450～550g）在完成手术后，被随机分为三个组：假手术组、心脏骤停对照组、红景天甙组（40 mg/kg）。除假手术组外，大鼠心脏骤停模型通过右颈外静脉置管的导丝电诱颤实现。ROSC后6 h，持续监测患者血流动力学（HR、MAP、ETCO₂）。在ROSC 0、ROSC 1、3、6 h测量心功能：大鼠射血分数（EF）、心输出量（CO）、心肌活动指数（MPI），舌下微循环：微血管流动指数（MFI）和灌注微血管密度（PVD）。结果：红景天甙可改善大鼠ROSC后1、2、3h的MAP，但在其他时间段对MAP并无显著的影响。红景天甙组对复苏后大鼠的HR和ETCO2无显著影响。同时，红景天甙可显著提高心脏骤停后鼠EF和CO，降低MPI。红景天甙可显著提高复苏后MFI和PVD。结论：红景天甙通过改善复苏后“无复流现象”，减轻心肺复苏后心功能不全。更多还原

【Abstract】 Objective:To investigate the protective effect of Salidrosideon post-resuscitated myocardial dysfunc-tion.Methods:18 Sprague-Dawley rats weighing between 450-550 g were randomized into 3 groups:Sham,Cardiac Arrest group,Salidroside group（40 mg/kg）.VF was induced through a guide wire advanced from the right jugular vein into the right ventricle.Hemodynamics parameters（HR,MAP,ETCO₂）were continuously recorded during ROSC 6 h,and echocardiography（ejection fraction,EF;cardiac output,CO;and myocardial performance index,MPI） and sublin-gual microcirculation（microvascular flow index,MFI;perfused microvessel density,PVD）were measured at ROSC 0,1,3,6 h.Results:Salidroside significantly increased post-arrest rat MAP at ROSC 1,2,3 h,thereafter there wereno sig-nificant differences among the three group.No significant differences of HR and ETCO₂were found between salidroside group and cardiac arrest group.However,salidroside markedly improved post-arrest myocardial function,as evidenced by increased EF and CO,shorten MPI.Conccurently,salidroside successfully prevent no-reflow phenomenon by increas-ing MPI and PVD.Conclusion:Salidroside ameliorated post-resuscitated myocardial dysfunction by preventing no-reflow phenomenon.更多还原