【摘要】 建立顶空气相色谱法，同时测定雌二醇中的残留溶剂甲醇和乙醇。采用以6%氰丙基和94%二甲基聚硅氧烷为固定相的毛细管柱作为色谱柱，用氢火焰离子化检测器检测。方法学验证结果表明：甲醇质量浓度为2.01～20.1μg/m L时残留溶剂线性关系良好（r=0.999 8），乙醇质量浓度为2.00～24.0μg/m L时残留溶剂线性关系良好（r=0.999 8）；甲醇回收率分别为106.9%、102.2%、100.8%，乙醇回收率为104.3%、103.8%、105.9%。该方法专属性强、灵敏度高、准确性好，可用于雌二醇中残留溶剂的测定。更多还原

【Abstract】 The paper established a headspace gas chromatography method and simultaneously determined the residual solvents methanol and ethanol in estradiol. The paper uses a capillary column with 6% cyanopropyl and 94% dimethylpolysiloxane as stationary phases as the chromatographic column, and is detected by a hydrogen flame ionization detector. The methodological validation results indicate that methanol ranges from 2.01 to 20.1 μ. The linear relationship is good within the range of g/mL(r=0.999 8), and ethanol ranges from 2.00 to 24.0 μ. The linear relationship is good within the range of g/mL(r=0.999 8); The recovery rates of methanol are 106.9%, 102.2%, and 100.8%, respectively, while the recovery rates of ethanol are 104.3%, 103.8%, and105.9%. This method has strong specificity, high sensitivity, and good accuracy, and can be used for the determination of residual solvents in estradiol.更多还原