【摘要】 目的探讨帕瑞昔布复合地佐辛在胫腓骨骨折切开复位内固定术超前镇痛中的应用效果。方法选取2017年3月至2019年12月拟在本院行切开复位内固定术治疗的80例胫腓骨骨折患者,按随机数字表法分为两组,各40例。切皮前20 min,对照组静脉注射40 mg帕瑞昔布,实验组静脉注射40 mg帕瑞昔布和0.1 mg/kg地佐辛。观察比较两组麻醉相关指标、术后动态和静态疼痛程度。结果实验组意识恢复时间为(10.12±3.39)min、拔管时间为(8.05±2.15)min,均短于对照组;实验组SAS评分为(3.98±0.51)分,低于对照组,差异均有统计学意义(P<0.05);与对照组比较,实验组1 h、4 h、12 h和24 h时动态、静态视觉模拟评分法(VAS)评分较低,差异有统计学意义(P<0.05)。结论在胫腓骨骨折切开复位内固定术中使用帕瑞昔布复合地佐辛超前镇痛可有提高麻醉效果,减少苏醒期躁动发生,减轻术后疼痛程度。更多还原

【Abstract】 Objective To explore the effect of parecoxib combined with dizocine in the treatment of preemptive analgesia with open reduction and internal fixation for tibia and fibula fractures. Methods From March 2017 to December 2019, 80 cases of tibia and fibula fractures planned to be treated with open reduction and internal fixation in our hospital were selected and they were divided into two groups according to the random number table method, with 40 cases in each group. 20 minutes before skin incision, the control group was intravenously injected with 40 mg parecoxib, and the experimental group was intravenously injected with 40 mg parecoxib and 0.1 mg/kg dezocine. The anesthesia related indexes, postoperative dynamic and static pain levels were observed and compared between the two groups. Results The recovery time of consciousness in the experimental group was(10.12 ± 3.39) min, and the extubation time was(8.05 ± 2.15) min, which was shorter than that of the control group, and the SAS score(3.98±0.51) scores in the experimental group was lower than that of the control group(P<0.05). Compared with the control group, the dynamic and static visual analogue scoring(VAS) scores of the experimental group at 1 h, 4 h, 12 h and 24 h were lower, and the difference was statistically significant(P<0.05). Conclusion The use of parecoxib combined with dezocine for analgesia during open reduction and internal fixation of tibia and fibula fractures can improve the anesthesia effect, reduce the occurrence of restlessness during recovery, and reduce the postoperative pain.更多还原