【摘要】 目的探讨芬太尼贴剂治疗消化道肿瘤中重度疼痛的成本-疗效分析。方法选取2014年1月至2017年12月间渭南市中心医院收治的81例消化道肿瘤中重度疼痛患者进行回顾性分析,将采用芬太尼贴剂镇痛的39例患者纳入芬太尼组,采用盐酸羟考酮缓释片镇痛的42例患者纳入羟考酮组,比较两组患者治疗后的疼痛缓解率、治疗前后的卡氏功能状态评分(KPS)、治疗期间的不良反应发生率及成本-效果。结果芬太尼组的疼痛缓解率为92.3%,羟考酮组为90.5%,组间比较,差异无统计学意义(P>0.05)。芬太尼组和羟考酮组治疗后的KPS评分均高于治疗前,差异均有统计学意义(均P<0.05)。两组患者治疗前后的KPS评分组间比较,差异无统计学意义(P>0.05)。芬太尼组的不良反应发生率为28.2%,低于羟考酮组的69.0%,差异有统计学意义(P<0.05)。芬太尼组的成本-效果高于羟考酮组。结论芬太尼贴剂与盐酸羟考酮缓释片分别治疗消化道肿瘤患者时,镇痛效果及改善患者生活质量疗效相当,芬太尼不良反应较少,盐酸羟考酮缓释片治疗成本较低,临床上需结合患者具体情况选择用药。更多还原

【Abstract】 Objective To investigate the cost-effectiveness of of fentanyl patch in treatment of moderate to severe pain in digestive tract tumors.. Methods A total of 81 patients with digestive tract tumors accompanied by moderate to serve pain at Weinan Central Hospital from January 2014 to December 2017 were selected and retrospectively analyzed. They were divided into the fentanyl group( 39 patients) and oxycodone group( 42 patients). Pain relief,the Karnofsky performance score( KPS) before and after treatment,the incidence of adverse reactions and cost-effectiveness were compared between the two groups.Results The pain relief rate was 92. 3% for fentanyl group after treatment and 90. 5% for the oxycodone group( P > 0. 05). The KPS scores was higher in offentanyl group and oxycodone group before theatment than after the treatment( all P < 0. 05). However,there was no significant difference in KPS scores between the two groups before and after treatment( P > 0. 05). The incidence of adverse reactions was 28. 2% for fentanyl group,was obvious lower than 69. 0% of the oxycodone group( P < 0. 05). The cost-effectiveness was higher in fentanyl group than in oxycodone group. Conclusion Fentanyl patch had equivalent efficacy in analgesia and quality of life improvement with the oxycodone group,with few adverse reactions and low cost,who should be administered according to patients’ specific situation.更多还原