【摘要】 目的:分析我院29例由丙硫氧嘧啶(PTU)引起的抗中性粒细胞胞浆抗体(ANCA)阳性患者的临床特点,观察甲巯咪唑(MMI)替代治疗出现ANCA相关性小血管炎(AASV)患者的改善情况。方法:29例的临床资料,采用一般临床检查和实验室检查,对其临床表现、治疗和预后进行回顾性分析。结果:ANCA阳性而无临床症状16例(55.2%),出现AASV的患者13例(44.8%),其中环核型ANCA(pANCA)阳性患者肾受累的发生率(50.0%)高于胞浆型ANCA(cANCA)阳性患者(40.0%);采用MMI替代治疗1年后ANCA转阴率66.7%。结论:由PTU引起的AASV,采用MMI替代治疗后,病情得到改善。更多还原

【Abstract】 OBJECTIVE:To analyze the clinical characteristics of 29 patients with PTU-induced positive antineutrophil cytoplasmic antibody(ANCA),and to investigate the effects of replacement treatment of MMI on ANCA-associated small vessel vasculitis (AASV). METHODS:By general clinical examination and laboratory examination,clinical information of 29 positive ANCA cases were analyzed retrospectively in respect of their clinical manifestations,treatment and prognosis. RESULTS:No clinical manifestation was found in 16 cases of PTU induced positive ANCA(55.2%);AASV was found in 13 cases(44.8%);the incidence of renal involvement in patients with pANCA(50.0%)were significantly higher than those with cANCA(40.0%);MMI could relieve the ANCA at a rate of 66.7%. CONCLUSION:Replacement treatment of MMI can relieve PTU-induced AASV.更多还原