【摘要】 目的:评价血凝酶与抑肽酶减少手术出血量的效果及安全性。方法:75例全髋关节置换术患者随机分为Ⅰ、Ⅱ、Ⅲ组,每组25例。术前15min,3组分别静脉注射血凝酶2kU、抑肽酶278IU、注射用水10ml。结果:Ⅰ、Ⅱ组术后24h出血量及术后输血量分别为(286.9±65.6)、(301.9±81.1)ml及(101.8±29.6)、(98.3±36.1)ml,比Ⅲ组的(369.2±59.3)、(220.2±48.5)ml显著减少(P<0.01)。3组术毕血红蛋白、血小板、纤维蛋白原比术前明显降低(P<0.01),但均在正常范围。Ⅱ组有1例发生严重过敏反应。结论:术中应用血凝酶或抑肽酶均有明显的止血效果,但血凝酶更安全。更多还原

【Abstract】 OBJECTIVE:To evaluate the efficacy of hemocoagulase and aprotinin in reducing bleeding volume and to evaluate their medication safety.METHODS:75 patients undergoing total hip replacement were randomly assigned to receive hemocoagulase 2kU(Group Ⅰ),aprotinin 278IU(Group Ⅱ)or water for injection 10ml(Group Ⅲ)intravenously before operation,with 25 cases in each group.RESULTS:Total 24h bleeding volume vs.blood infusion volume after operation in Group Ⅰ and Group Ⅱ were(286.9± 65.6)ml vs.(301.9± 81.1)ml and(101.8± 29.6)ml vs.(98.3± 36.1)ml,respectively,which were significantly lower as against Group Ⅲ(369.2± 59.3)ml vs.(220.2± 48.5)ml(P<0.01).Postoperative levels of Hb,BPC and FIB were significantly lowered as against before operation(P<0.01),but still within normal range.Severe allergic response occurred in one case of Group Ⅱ.CONCLUSION:Perioperative use of either hemocoagulase or aprotinin exhibits good hemostatic efficacy,but hemocoagulase is better in safety.更多还原