【摘要】 目的 探讨去甲肾上腺素联合垂体后叶素治疗感染性休克的临床效果。方法 选取2017年9月至2023年5月扬州市中医院ICU收治的62例感染性休克患者作为研究对象，按照随机数字表法分为观察组和对照组，每组各31例。对照组在常规的补液、抗感染等治疗的基础上加用去甲肾上腺素维持血压，观察组在对照组的基础上加用垂体后叶素，统计两组治疗后第6、24、48及72 h血乳酸和尿量变化情况，统计两组6 h内的液体复苏成功率、28 d病死率以及不良反应状况。结果 治疗后观察组6、24、48及72 h血乳酸下降水平高于对照组，差异有统计学意义（P<0.05）；治疗后观察组6、24、48及72 h尿量高于对照组，差异有统计学意义（P<0.05）；同时观察组6 h内液体复苏成功率高于对照组，且观察组28 d病死率低于对照组，差异有统计学意义（P<0.05）；两组不良反应总发生率的比较，差异无统计学意义（P>0.05）。结论 去甲肾上腺素联合垂体后叶素治疗感染性休克能改善患者的血乳酸及尿量，提高6 h内的液体复苏成功率，并且降低28 d死亡率，安全性有保障。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Norepinephrine combined with Pituitrin in the treatment of septic shock. Methods A total of 62 patients with septic shock admitted to ICU of Yangzhou Hospital of Traditional Chinese Medicine from September 2017 to May 2023 were selected as the study objects, and they were divided into observation group and control group according to random number table method, with 31 cases in each group. The control group was treated with Norepinephrine on the basis of routine fluid rehydration and anti-infection treatment to maintain blood pressure, while the observation group was treated with Pituitrin on the basis of the control group. The changes of blood lactic acid and urine volume at 6, 24, 48 and 72 h after treatment of the two groups were counted, and the success rate of fluid resuscitation within 6 h, 28-day mortality and adverse reactions of the two groups were counted. Results After treatment, the decrease level of blood lactic acid in observation group at 6, 24, 48 and 72 h were higher than those in control group, and the differences were statistically significant(P<0.05). After treatment, urine volume at 6, 24, 48 and 72 h in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). The success rate of fluid resuscitation within 6 h in the observation group was higher than that in the control group, and the 28-day fatality rate in the observation group was lower than that in the control group, the differences were statistically significant(P<0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion The combination of Norepinephrine and Pituitrin in the treatment of septic shock can improve patients’ blood lactate levels and urine output, increase the success rate of fluid resuscitation at 6 hours, and reduce the 28-day mortality rate. This treatment approach may offer clinical benefits for patients with septic shock, the security of this method is guaranteed.更多还原