【摘要】 目的研究老年高血压患者血清胱抑素C(cystatin-C,Cys-C)水平与认知障碍的相关性。方法将2017年10月～2019年3月就诊于武警陕西总队医院门诊及住院的老年高血压患者320例纳入研究,检测患者血清胱抑素C水平。依据简易智力量表评分结果,分为无认知障碍组(256例)和认知障碍组(64例)。结果认知障碍组收缩压及舒张压均高于无认知障碍组,差异有统计学意义(t=-2. 993,-2. 063,P=0. 005,0. 05)。认知障碍组血清胱抑素C水平显著高于无认知障碍组,差异有统计学意义(t=-3. 567,P=0. 001)。结论老年高血压患者发生认知障碍与血清胱抑素C水平及血压的高低有密切的相关性,提示在临床工作中,应重视积极控制血压并监测血清胱抑素C水平,对预防认知障碍的发生、发展有重要的临床意义。更多还原

【Abstract】 Objective To study the correlation between serum cystatin-C( Cys-C) level in elderly patients with hypertension and congnitive impairment. Methods 320 hypertension patients admitted to Shaanxi Armed Police Corps Hospital outpatitent and hospitalization from October 2017 to March 2019 were included in the study,and Cys-C were measured. Based on the simple intelligence scale,the patients were divided into two groups,256 cases without cognitive impairment and 64 cases with cognitive impairment. Results Systolic and diastolic blood pressure in the group with cognitive impairment were significantly higher than the non-cognitive impairment group( t =-2. 993,-2. 063,P = 0. 005,0. 05). The serum Cys-C level in the group with cognitive impairment was significantly higher than the non-cognitive impairment group,and the difference was statistically significant( t =-3. 567,P = 0. 001). Conclusion Cognitive impairment in elderly patients with hypertension is closely related with serum Cys-C level and blood pressure. It suggested that attention should be paid to the active control of blood pressure and monitoring of serum Cys-C levels in clinical work. It has important clinical significance to prevent the occurrence and development of cognitive impairment.更多还原