【摘要】 目的 探讨血清胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)和癌胚抗原(CEA)联合检测对小细胞肺癌(SCLC)的诊断价值。方法 471例肺部肿瘤患者均来自呼吸内科和胸外科住院患者,另从健康查体中心随机选取162例健康人作为对照组。所有研究对象均空腹采血,采用电化学发光法检测其血清ProGRP,NSE和CEA水平,绘制ROC曲线并计算曲线下面积(the area underthe curve,AUC)。结果 SCLC患者血清ProGRP和NSE水平显著高于非小细胞肺癌组、肺良性病变组和正常对照组(P<0.01)。SCLC患者血清CEA水平显著高于肺良性病变组和正常对照组(P<0.05)。ProGRP,NSE和CEA诊断SCLC的AUC分别为0.933,0.777和0.554。ProGRP,NSE和CEA诊断SCLC的敏感度分别为82.6%,60.4%和41.6%,特异度分别为95.2%,83.3%和71.7%。联合检测ProGRP,NSE和CEA诊断SCLC的敏感度为91.3%,特异度为65.3%。结论 血清ProGRP检测对SCLC具有较高的诊断价值;ProGRP,NSE和CEA的联合检测有助于SCLC的早期诊断。更多还原

【Abstract】 Objective To investigate the diagnostic value of combined detection of serum gastrin-releasing peptide precursor(ProGRP),neuron specific enolization enzyme(NSE) and carcinoembryonicantigen(CEA) in small cell lung cancer(SCLC).Methods 471 patients with lung tumor from department of respiratory medicine and thoracic surgery and 162 healthy people from medical examination center were studied.Serum levels of ProGRP,NSE and CEA were detected by using electrochemical luminescence method.ROC curves were drawn and the area under the curve(AUC) was calculated.Results The levels of ProGRP and NSE were significantly higher in patients with SCLC than those in NSCLC,lung benign disease group and normal control group(P<0.01).The levels of CEA were significantly higher in SCLC than those in patients with lung benign disease group and normal control group(P<0.05).The AUC of ProGRP,NSE and CEA in the diagnosis of SCLC were 0.933,0.777 and 0.554,respectively.The sensitivity of ProGRP,NSE and CEA in the diagnosis of SCLC were82.6%,60.4%,41.6%and the specificity were 95.2%,83.3%and 71.7%respectively.The sensitivity of combined detection of ProGRP,NSE and CEA was 91.3%and the specificity was 65.3%.Conclusion The serum ProGRP detection has a higher diagnostic value for SCLC.The combined detection of ProGRP,NSE and CEA is useful in the early diagnosis of SCLC.更多还原