【摘要】 目的初步总结分析我科经鼻内镜治疗垂体腺瘤的治疗效果和经验,进一步推广内镜操作理念。方法回顾性分析采用经鼻内镜手术治疗47例垂体腺瘤的临床资料,观察其肿瘤切除程度,内分泌缓解情况和术后住院时间、脑脊液漏、颅内感染等。结果其中42例(89. 4%)全切,5例(10. 6%)次全切。所有病例随访6～26个月,患者头痛症状均明显缓解,视力改善31例,颅神经麻痹7例均恢复。出现颅内感染2例,未见永久性垂体功能低下的出现。结论经鼻内镜治疗垂体腺瘤,手术切除率高,并发症低,疗效确切,术后鞍底多层修复能明显减少脑脊液漏和颅内感染的风险,临床应用前景好。更多还原

【Abstract】 Objective The clinical outcome and experience of pituitary resection by endonasal endoscopy,and promote operation concept were summarized. Methods Clinical data of 47 patients with pituitary adenoma treated by endonasal endoscopy were analyzed retrospectively,and the degree of tumor resection,endocrine amelioration,postoperative hospitalization,cerebrospinal fluid leak and intracranial infection were shown. Results The postoperative MRI revealed complete resection in 42 cases( 89. 4%) and sub-total resection in 5 cases( 10. 6%). All patients were followed up for 6 to 26 months. Improvements of patients included headaches disappearance( all),eyesight improvement( 31 cases) and cranial nerve palsies improvement( 7 cases). There were 2 cases of intracranial infection. No permanent hypopituitarism was found. Conclusion Surgical treatment of pituitary adenoma by endonasal endoscopy advantages in achieving complete tumor resection and reducing complications. The multilayer repair can significantly reduce the incidence of cerebrospinal fluid rhinorrhea and intracranial infection. There are bright prospects in clinic application.更多还原