【摘要】 原发性牙齿萌出障碍(PFE)是一种比较罕见的牙齿萌出异常性疾病,它是由于萌出机制本身异常而导致的牙齿萌出障碍,而非其他局部或全身因素所致。发病机制尚不十分明确,可能与基因突变有关,甲状旁腺激素受体1(PTH1R)突变是已经被证实的病因之一。临床表现以牙齿萌出不全和后牙开(牙合)为主要特征,正畸牵引无效。因其具有明显的家族聚集性,基因遗传分析是必要的辅助检查手段,对PFE的筛查、诊断和治疗具有重要意义。目前PFE尚无较好的治疗方法,可摘局部义齿、种植义齿和外科手术治疗等是可以参考的治疗手段。该文将从PFE的发病机制、临床特征、诊断和治疗等方面的研究现状作一综述。更多还原

【Abstract】 Primary failure of eruption(PFE) is a rare abnormal tooth eruption disorder, which is caused by an abnormal mechanism of tooth eruption rather than other local or systemic factors. The pathogenesis is not very clear and may be related to gene mutations. Mutation of parathyroid hormone receptor 1(PTH1 R) is one of the proven etiologies. The clinical manifestations are mainly characterized by incomplete tooth eruption and posterior teeth open bite. Orthodontic extrusion is ineffective. Due to its obvious family aggregation, genetic analysis is a necessary auxiliary examination method, which is of great significance to the screening, diagnosis and treatment of PFE. There is no effective treatment method for PFE at present. Removable partial denture, implant denture and surgical treatment are available for reference. The aim of this study is to systematically evaluate the pathogenesis, clinical characteristics, diagnosis and treatment of PFE.更多还原