【摘要】 探索影响呋塞米口服液稳定性的因素，并预测其有效期。采用加速稳定性实验的方法，研究温度、光照、存放时间等因素对呋塞米口服液稳定性的影响，确定降解反应的级数，计算25℃的降解速度常数(K_25℃)和有效期。结果表明，高温、光照、时间对呋塞米口服液稳定性影响较大，降解反应为一级；t=25℃,有效期为305 d;呋塞米口服液需棕色玻璃瓶灌装，阴凉避光保存。更多还原

【Abstract】 In order to explore the factors that affect the stability of furosemide oral solution and predict its validity, an accelerated testing method was used.The methods were used to study the effects of temperature, light and storage time on the stability of furosemide oral solution, and calculate the degradation rate constant(K_{25 ℃}) and validity period of furosemide oral solution at 25 ℃.The results indicated that the furosemide oral solution was unstable in case of light, temperature, and gradually decomposed with time.The degradation reaction is one grade, and the validity is 305 days at 25 ℃.It was recommended that the furosemide oral solution should be filled in a brown glass bottle and stored in a cool, dark place.更多还原