【摘要】 目的：建立离子色谱法测定左氧氟沙星氯化钠注射液中的氯化钠含量方法。方法：用阳离子交换柱Dionex IonPacTMCS12A(250 mm×4 mm)；保护柱：DionexIonPacTM CG12A(50 mm×4 mm)；以20 mmol/L甲烷磺酸溶液为流动相，等度洗脱；采用阳离子抑制器和电导检测器检测；流速：1.0 mL/min；柱温：30℃；进样体积：25μL。结果：钠离子在20～60μg/mL范围内呈良好的线性关系，相关系数r=1.0；重复性实验RSD为0.31%；中间精密度RSD为0.36%；平均加样回收率为98.5%；样品在48 h内稳定；柱温和流速在一定范围内改变，对检测结果无影响。结论：该方法可准确测定左氧氟沙星氯化钠注射液中氯化钠含量。更多还原

【Abstract】 Objective: To establish an ion chromatography method for determining the content of sodium chloride in levofloxacin sodium chloride injection. Method: Dionex IonPacTMCS12A(250 mm × 4 mm) cation exchange column was used. Protective column: Dionex InPacTM CG12A(50 mm x 4 mm). Using a 20 mmol/L methane sulfonic acid solution as the mobile phase, perform isocratic elution. Using cation suppressors and conductivity detectors for detection. Flow rate: 1.0 m L/min. Column temperature: 30 ℃. Injection volume: 25 μL.Result: Sodium ions showed a good linear relationship in the range of 20～60 μg/m L, with a correlation coefficient of r=1.0. The RSD of the repeatability experiment is 0.31%. Intermediate precision RSD=0.36%. The average sample recovery rate is 98.5%. The sample remains stable within 48 hours. Changing the column temperature and flow rate within a certain range has no effect on the detection results.Conclusion: This method can accurately determine the content of sodium chloride in levofloxacin sodium chloride injection.更多还原