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水凝胶在视网膜疾病治疗中的研究进展

Research advances of hydrogels in the treatment of retinal diseases

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【作者】 徐静逸胡仔仲谢平

【Author】 XU Jingyi;HU Zizhong;XIE Ping;Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University;

【通讯作者】 谢平;

【机构】 南京医科大学第一附属医院眼科

【摘要】 水凝胶是一种具备多领域应用潜能的前沿高分子材料,凭借其良好的生物相容性、高效的药物载荷能力、可智能调控的机械和生物性能,成为组织工程、生物医学工程等领域的研究热点之一。近年来,水凝胶在眼科领域也得到了广泛研究,文章首先介绍了水凝胶的制备方法和成胶特性,然后从抗新生血管、抗氧化和抗炎、玻璃体替代等方面探讨了其在年龄相关性黄斑变性、糖尿病视网膜病变、视网膜脱离等主要视网膜疾病中的应用前景,以期为未来的研究和临床应用提供参考。

【Abstract】 Hydrogels are cutting-edge polymeric materials with potential applications across various fields. They have become one of the hot topics in research areas such as tissue engineering and biomedical engineering,thanks to their good biocompatibility,efficient drug-loading capacity,and intelligently tunable mechanical and biological properties. In recent years,hydrogels have also been widely studied in the field of ophthalmology. This review first introduces the preparation methods and gelation characteristics of hydrogels,and then discusses their application prospects in major retinal diseases such as age-related macular degeneration,diabetic retinopathy,and retinal detachment from aspects of anti-angiogenesis,antioxidant,anti-inflammatory effects,and vitreous substitutes,aiming to provide reference and guidance for future research and clinical applications.

【基金】 江苏省科技厅重点项目(社发)(BE2021744)
  • 【文献出处】 南京医科大学学报(自然科学版) ,Journal of Nanjing Medical University(Natural Sciences) , 编辑部邮箱 ,2025年05期
  • 【分类号】R774.1
  • 【下载频次】129
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