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布地奈德联合沙丁胺醇治疗哮喘儿童的疗效及其对患儿肺功能及生活质量的影响

Clinical efficacy of budesonide combined with albuterol aerosol in the treatment of children with asthma and its effect on lung function and quality of life

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【作者】 魏妮康永平

【Author】 WEI Ni;KANG Yong-ping;Department of Pediatrics,Weinan Maternal and Child Health Hospital;Department of Pediatrics,Baoji Fengxiang District Hospital of Traditional Chinese Medicine;

【通讯作者】 康永平;

【机构】 渭南市妇幼保健院儿科宝鸡市凤翔区中医医院儿科

【摘要】 目的 观察布地奈德联合沙丁胺醇气雾剂治疗儿童哮喘急性发作的临床疗效,并探讨其对患儿肺功能及生活质量的影响。方法 选取渭南市妇幼保健院儿科及宝鸡市凤翔区中医医院儿科2019年8月至2020年5月期间收治的急性哮喘患儿100例,采用随机数表法分为观察组和对照组,每组50例。两组患儿均予以括吸氧、抗感染、解痉平喘、纠正酸碱平衡紊乱等常规综合治疗,对照组患儿同时采用沙丁胺醇气雾剂雾化吸入治疗,观察组患儿在常规治疗的基础上加用布地奈德雾化吸入治疗,两组患儿均治疗7 d。比较两组患儿治疗后的临床疗效,以及治疗前后的生活质量[采用生活质量调查问卷(PAQLQ)评价],同时比较两组患儿治疗前后的肺功能变化[第一秒用力呼气容积(FEV1)、最大呼气流量(PEF)]。结果 观察组患儿的治疗总控制率为94.00%,明显高于对照组的78.00%,差异有统计学意义(P<0.05);治疗后,观察组和对照组患儿的FEV1[(93.62±16.97)%vs (83.12±19.54)%]及PEF [(94.11±18.76)%vs (84.02±17.16)%]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组和对照组患儿的症状[(6.11±1.56)分vs (4.42±1.46)分]、活动[(6.09±1.44)分vs (4.37±1.54)分]、情感[(6.29±1.52)分vs (4.60±1.61)分]的评分比较,观察组明显高于对照组,差异均有统计学意义(P<0.05)。结论 布地奈德混悬液联合沙丁胺醇气雾剂雾化吸入可有效改善哮喘儿童临床症状,提高临床疗效及生活质量,值得临床推广使用。

【Abstract】 Objective To observe the clinical efficacy of budesonide combined with albuterol aerosol in the treatment of acute asthma in children, and to explore its effect on children’s lung function and quality of life. Methods A total of 100 children with acute asthma who were admitted to the Department of Pediatrics, Weinan Maternal and Child Health Hospital and Department of Pediatrics, Baoji Fengxiang District Hospital of Traditional Chinese Medicine from August2019 to May 2020 were selected and divided into an observation group and a control group by random number table method, with 50 patients in each group. Both groups of children were given conventional comprehensive treatment, including oxygen inhalation, anti-infection, antispasmodic and anti-asthmatic treatment, correction of acid-base balance disorder. Children in the control group were also given inhalation therapy of albuterol aerosol, and the children in the observation group were treated with budesonide combined with albuterol aerosol, both for 7 days. The clinical efficacy,quality of life before and after treatment [assessed by quality of life questionnaire(PAQLQ)] were compared between the two groups. The changes of pulmonary function [forced expiratory volume in one second(FEV1), peak expiratory flow(PEF)] before and after treatment were also compared between the two groups. Results The total control rate of the observation group was 94.00%, which was significantly higher than 78.00% of the control group(P<0.05). After treatment,FEV1 and PEF in the observation group were significantly higher than those in the control group(P<0.05): FEV1,(93.62±16.97)% vs(83.12±19.54)%; PEF,(94.11±18.76)% vs(84.02±17.16)%. After treatment, the scores of symptoms, activities, and emotions in the observation group were significantly higher than those in the control group(P<0.05): the scores of symptoms,(6.11±1.56) points vs(4.42±1.46) points; activities,(6.09±1.44) points vs(4.37±1.54) points; emotions,(6.29±1.52) points vs(4.60±1.61) points. Conclusion Budesonide combined with albuterol aerosol inhalation can effectively improve the clinical symptoms of children with asthma, improve the clinical efficacy and quality of life, which is worthy of clinical application.

【关键词】 儿童哮喘布地奈德沙丁胺醇肺功能疗效
【Key words】 ChildrenAsthmaBudesonideAlbuterolPulmonary functionClinical efficacy
  • 【文献出处】 海南医学 ,Hainan Medical Journal , 编辑部邮箱 ,2022年12期
  • 【分类号】R725.6
  • 【下载频次】11
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