【摘要】 环状RNA (circRNA)是一类内源性非编码RNA,是由线性RNA经反向剪切形成的闭合环状结构,广泛存在于真核细胞中,且可在多种体液中检测到,具有结构稳定、高度保守以及表达具有特异性等特点,是肿瘤的重要调节因子。circRNA主要通过吸附微小RNA (miRNA)或者RNA结合蛋白(RBP)发挥"海绵作用",进而调控下游靶基因表达,在多种疾病尤其在肿瘤中发挥重要功能,包括参与肿瘤细胞的增殖、迁移、侵袭、细胞周期、凋亡、上皮间充质转化和信号通路传导等多种生物学过程。近来研究发现,circRNA对肝细胞癌(HCC)的发生和发展具有重要调控作用,有望成为HCC诊断的生物标志物及治疗靶点。笔者就circRNA在HCC发生发展中的作用的研究进展进行综述。更多还原

【Abstract】 CircularRNAs(circRNAs) are a class of endogenous non-codingRNAs, with a closed circular structure formed through the back-splicing of linearRNAs. CircRNAs widely exist in eukaryotic cells and can be detected in many types of body fluid samples, presenting with stable structure, highly conserved and specific expression, and are important regulators of tumors. CircRNAs exert a "sponge action" mainly by adsorbing microRNAs(miRNAs) orRNA binding proteins(RBPs) to regulate the expression of downstream target genes, and play important role in a variety of diseases, especially in tumors. They are involved in many biological processes such as proliferation, migration, invasion, cell cycle, apoptosis,epithelial-mesenchymal transformation and signaling pathway of tumor cells. Recent studies have shown that circRNAs have critical regulatory functions affecting the occurrence and development of hepatocellular carcinoma(HCC), and they are expected to become the diagnostic biomarkers and therapeutic targets of HCC. Here, the authors address the research progress of the roles of circRNAs in the initiation and progression of HCC.更多还原