【摘要】 目的探讨蛛网膜下腔出血（ＳＡＨ）后脑血管痉挛（ＣＶＳ）的发病机理和防治方法。方法采用放免法动态观察了犬ＳＡＨ后血浆、ＣＳＦ中神经肽Ｙ（ＮＰＹ）、心钠素（ＡＮＰ）含量动态变化及巴曲酶的保护作用。结果单纯注血组及巴曲酶治疗组血浆、ＣＳＦ中ＮＰＹ、ＡＮＰ含量较注血前及同期正常对照组明显增高（Ｐ＜０．０１）；单纯注血组在注血后３０ｍｉｎ血浆、ＣＳＦ中ＮＰＹ含量开始升高，ＣＳＦ中ＡＮＰ含量亦在注血后３０ｍｉｎ升高，血浆ＡＮＰ含量则在第２ｄ开始升高，至第７ｄ最高。蛛网膜下腔给药组和静脉注入巴曲酶０．４ＢＵｋｇ－１ｄ－１组血浆、ＣＳＦ中ＮＰＹ、ＡＮＰ含量均明显低于同期单纯注血组（Ｐ＜０．０１）。结论血浆、ＣＳＦ中ＮＰＹ、ＡＮＰ的异常增高是ＳＡＨ后ＣＶＳ的原因之一，巴曲酶可以防止ＮＰＹ和ＡＮＰ的异常增高。更多还原

【Abstract】 Objective To study the effect mechanism of NPY and ANP on CVS following experimental dog SAH and neuroprotective effects of Bitroxobin.Method The measure of NPY and ANP in plasma and CFS was used by radio immunological analysis.Results The levels of NPY、ANP in both plasma and CFS in groups of simple injecting blood and treatment using Batroxobin increased more than that in groups of preinjecting blood and control(P<0.01).After injecting blood for 30min,the level of NPY in plasma and CSF started to increase,ANP also increased in CSF.After injecting blood the 2nd day,ANP in plasma started to increase.Upto the seventh day after injecting blood,ANP in plasma was the highest.NPY and ANP in plasma and CFS in groups of injecting Batroxobin into subarochnoid and vein were lower than that in the group of simple injecting blood (P<0.01).Conclusin One of the reasons of CVS after SAH was due to the abnormal increasing of NPY and ANP in plasma and CFS.Batroxobin could protect abnormal increasing of NPY and ANP in plasma and CFS.更多还原