【摘要】 目的：分析探讨补肺固元膏对慢性阻塞性肺疾病频繁急性加重表型的应用。方法：选取2020年1月-2021年1月在衡阳市中医医院治疗的慢性阻塞性肺疾病频繁急性加重表型的患者160例，随机分为两组，各80例。对照组单纯吸入布地奈德福莫特罗吸入粉雾剂，研究组在对照组基础上加用补肺固元膏。对比治疗前后两组的中医症候积分、肺功能、炎症因子水平。结果：治疗后，研究组的中医症候积分、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、嗜酸性粒细胞（EOS）水平均低于对照组，差异有统计学意义（P<0.05）。治疗后，研究组的第1秒用力呼气容积（FEV₁）、一秒率（FEV₁/FVC）高于对照组，差异均有统计学意义（P<0.05）。结论：采用补肺固元膏对慢性阻塞性肺疾病频繁急性加重表型进行治疗临床效果佳，具有临床意义。更多还原

【Abstract】 Objective:To analyze and explore the application of Bufei Guyuan Ointment on the phenotype of frequent acute exacerbation of chronic obstructive pulmonary disease.Method:A total of 160 patients with frequent acute exacerbation phenotype of chronic obstructive pulmonary disease from January 2020 to January 2021 in Traditional Chinese Medicine Hospital of Hengyang City were selected,and randomly divided into two groups,80 cases in each group.The control group only inhaled Budesonide Formoterol Powder Spray,while the study group added Bufei Guyuan Ointment on the basis of the control group.The traditional Chinese medicine symptom score,pulmonary function and inflammatory factors levels of the two groups were compared before and after treatment.Result:After treatment,the traditional Chinese medicine symptom score,tumor necrosis factor-α （TNF-α）,interleukin-6 （IL-6） and eosinophil（EOS） in the study group were lower than those in the control group,the differences were statistically significant （P<0.05）.After treatment,the forced expiratory volume in one second （FEV₁） and one second rate （FEV₁/FVC） in the study group were higher than those in the control group,the differences were statistically significant （P<0.05）.Conclusion:The clinical effect of Bufei Guyuan Ointment on chronic obstructive pulmonary disease with frequent acute exacerbation is good and has clinical significance.更多还原