【摘要】 目的:探讨老年冠心病患者血小板-白细胞聚集体(PLA)的表达及其意义。方法 :选择我院内科2010年1月至2012年12月期间收治的冠心病患者162例,分为稳定型心绞痛(SAP)组(92例),急性冠脉综合征(ACS)组(70例),选择同期非冠心病患者80例为正常对照组。比较3组间PLA、血小板-中性粒细胞聚集体(PNA)、血小板淋巴细胞聚集体(PLyA)和血小板-单核细胞聚集体(PMA)的水平,采用Spearman相关分析分析PLA与有关临床指标的相关性。结果:与正常对照组和SAP组比较,ACS组PLA[(2.23±1.20)%比(3.25±2.16)%比(4.36±2.65)%]、PMA[(15.3±7.6)%比(23.5±19.7)%比(32.4±19.6)%]、PNA[(1.85±0.89)%比(2.14±1.56)%比(3.64±4.65)%]和PLyA[(1.38±0.78)%比(1.42±0.87)%比(2.06±1.28)%]水平显著升高(P均<0.01),且SAP组PLA、PMA水平显著高于正常对照组(P<0.01)。Spearman相关性分析显示:冠心病患者PLA与血糖、甘油三酯呈正相关(r1=0.680,P1=0.030;r2=0.738,P2=0.015),与高密度脂蛋白胆固醇呈负相关(r=-0.722,P=0.018)。结论:PLA、PMA水平升高提示可能有老年冠心病,甚至是急性冠脉综合征。更多还原

【Abstract】 Objective:To investigate expression of platelet-leukocyte aggregates(PLA)and its significance in aged patients with coronary heart disease(CHD).Methods:A total of 162 CHD patients,who visited to our hospital from Jan 2010 to Dec 2012,were divided into stable angina pectoris(SAP)group(n=92)and acute coronary syndrome(ACS)group(n=70).Another 80 patients without CHD were selected as normal control group.Levels of PLA,platelet-neutrophil aggregates(PNA),platelet lymphocyte aggregates(PLyA)and platelet-monocyte aggregates(PMA)were compared among three groups.Spearman correlation analysis was used to analyze the correlation among relative indexes and PLA.Results:Compared with normal control group and SAP group,there were significant rise in levels of PLA [(2.23±1.20)% vs.(3.25±2.16)% vs.(4.36±2.65)%],PMA [(15.3±7.6)% vs.(23.5±19.7)% vs.(32.4±19.6)%],PNA [(1.85±0.89)% vs.(2.14±1.56)% vs.(3.64±4.65)%]and PLyA[(1.38±0.78)% vs.(1.42±0.87)% vs.(2.06±1.28)%]in ACS group,P<0.01 all,and PLA and PMA levels in SAP group were significantly higher than those of normal control group(P<0.01).Spearman correlation analysis indicated that PLA was positively correlated with blood glucose and triglyceride(r1=0.680,P1=0.030;r2=0.738,P2=0.015),and inversely correlated with HDL-C(r=-0.722,P=0.018)in CHD patients.Conclusion:Increased PLA and PMA levels indicate that there may be CHD disease,even acute coronary syndrome.更多还原