【摘要】 嵌合抗原受体T细胞免疫疗法(CAR-T疗法)是一种治疗肿瘤的新免疫疗法,通过向患者自身T细胞中导入已被修饰的CAR基因,使T细胞表达结合肿瘤表面抗原的特异性受体来实现对肿瘤的精准治疗.目前已发展到第四代.该免疫疗法在血液瘤和实体瘤治疗中都有一定疗效,同时也存在一些待解决难题.本文就近年来CAR-T在血液瘤和实体瘤中的研究治疗进展及存在的问题进行综述.更多还原

【Abstract】 CAR-T therapy is a novel therapy to treat tumors. It has realized the precise treatment of tumors by transforming the modified CAR gene into patients’ self T cells, driving the T cells expressing specific antibodies which are able to bind surface antigens to tumors. CAR-T has been in its fourth generation since put forward. This therapy exists both certain effects and risks in blood tumors as well as solid tumors but exposes some difficulty waited to be solved. In this review, we describe the treatment and existing problems of CAR-T therapy in blood tumors and solid tumors.更多还原