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Effect of the pineal gland on 5-hydroxytryptamine and γ-aminobutyric acid secretion in the hippocampus of male rats during the summer and winter

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【作者】 Ting LiHailu WangHewei ZhangLeilei LiuPeipei LiShuran Ma

【Author】 Ting Li;Hailu Wang;Hewei Zhang;Leilei Liu;Peipei Li;Shuran Ma;School of Traditional Chinese Medicine, Beijing University of Chinese Medicine;The First Affiliated Hospital of Soochow University;

【通讯作者】 Shuran Ma;

【机构】 School of Traditional Chinese Medicine, Beijing University of Chinese MedicineThe First Affiliated Hospital of Soochow University

【摘要】 Objective: The present study aimed to investigate the effect of seasonal variation on neurotransmitter release in the hippocampus of normal rats and rats with pineal excision.Methods: Two time points, the summer and winter solstice, which are the longest and shortest days of the year, respectively, were selected. Male Spraguee Dawley rats that underwent a sham operation without pineal excision were included as a control group. The concentrations of 5-hydroxytryptamine(5-HT) and γ-aminobutyric acid(GABA) were determined by radioimmunoassays and enzyme-linked immunosorbent assays, respectively.Results: In the winter, the 5-HT and GABA levels in normal rats exhibited a significant difference compared with those in the operation group(P <.01). A difference was also noted in GABA levels between the normal group and the sham operation group(P <.05). The concentrations of 5-HT and GABA in the hippocampal tissues of the normal group exhibited a seasonal rhythm consisting of elevation during the summer and reduction during the winter(P <.01), while the GABA levels in the sham operation group exhibited a significant difference, with elevation during the summer and reduction during the winter(P <.01). In the operation group, GABA showed the same trend(P <.01).Conclusion: The seasonal rhythm of neurotransmitter secretion by the hippocampus(5-HT and GABA)consisted of elevation during the summer and reduction during the winter. During the winter, the pineal gland exhibited a reverse regulatory effect on the secretion of 5-HT and GABA in the hippocampus, and it exhibited seasonal selectivity with regard to the regulation of 5-HT.

【Abstract】 Objective: The present study aimed to investigate the effect of seasonal variation on neurotransmitter release in the hippocampus of normal rats and rats with pineal excision.Methods: Two time points, the summer and winter solstice, which are the longest and shortest days of the year, respectively, were selected. Male Spraguee Dawley rats that underwent a sham operation without pineal excision were included as a control group. The concentrations of 5-hydroxytryptamine(5-HT) and γ-aminobutyric acid(GABA) were determined by radioimmunoassays and enzyme-linked immunosorbent assays, respectively.Results: In the winter, the 5-HT and GABA levels in normal rats exhibited a significant difference compared with those in the operation group(P <.01). A difference was also noted in GABA levels between the normal group and the sham operation group(P <.05). The concentrations of 5-HT and GABA in the hippocampal tissues of the normal group exhibited a seasonal rhythm consisting of elevation during the summer and reduction during the winter(P <.01), while the GABA levels in the sham operation group exhibited a significant difference, with elevation during the summer and reduction during the winter(P <.01). In the operation group, GABA showed the same trend(P <.01).Conclusion: The seasonal rhythm of neurotransmitter secretion by the hippocampus(5-HT and GABA)consisted of elevation during the summer and reduction during the winter. During the winter, the pineal gland exhibited a reverse regulatory effect on the secretion of 5-HT and GABA in the hippocampus, and it exhibited seasonal selectivity with regard to the regulation of 5-HT.

【基金】 supported by the National Natural Science Foundation of China (81774162)
  • 【文献出处】 Journal of Traditional Chinese Medical Sciences ,中医科学杂志(英文) , 编辑部邮箱 ,2020年03期
  • 【分类号】R338
  • 【被引频次】1
  • 【下载频次】9
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