【摘要】 目的 观察清热平喘汤联合西药治疗支气管哮喘急性期（热哮证）的临床疗效及对促炎因子的影响。方法 选取86例哮喘急性期热哮证患者采用随机数字表法将其分成观察组与对照组各43例。对照组患者予布地奈德/福莫特罗吸入剂联合孟鲁司特钠片治疗，观察组在对照组治疗基础上采用清热平喘汤，5 d为1个疗程，两组治疗2个疗程后观察临床疗效。比较两组治疗前后的主要症状评分、肺功能指标、哮喘控制测试量表（ACT）评分和促炎因子水平。结果 观察组临床总有效率为88.37%，明显高于对照组的69.77%(P <0.05)。观察组治疗后3、5、10 d的咳嗽、咯痰、气喘、胸闷症状评分明显低于对照组（P <0.05）。观察组治疗后第1秒用力呼气量占预计值百分比（FEV1）、第1秒用力呼气量/用力肺活量（FEV1/FVC）、最大呼气流量（PEF）水平明显高于对照组（P <0.05）。观察组治疗后ACT评分明显高于对照组，白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平明显低于对照组（P <0.05）。结论 对哮喘热哮证患者采用清热平喘汤联合西药治疗，疗效良好，对改善患者临床症状、肺功能具有显著效果，可有效降低促炎因子水平。更多还原

【Abstract】 Objective:To investigate the clinical efficacy of Qingre Pingchuan Decoction combined with western medicine in the treatment of acute bronchial asthma(heat wheezing syndrome)and its influence on pro-inflammatory factors. Methods:86 patients with acute bronchial asthma(heat wheezing syndrome)were divided into the observation group and control group by random number table method,43 cases in each group. Patients in the control group were treated with budesonide/formoterol inhalation plus montelukast sodium tables,and the observation group was treated with Qingre Pingchuan Decoction on the basis of the treatment of the control group,5 days was a course of treatment,and the clinical efficacy of the two groups was observed after 2 courses of treatment. The main symptom scores,lung function indexes,ACT scores and pro-inflammatory factor levels were compared between the two groups before and after treatment. Results:The total clinical effective rate of the observation group was 88.37%,which was significantly higher than the 69.77% of the control group(P < 0.05). The scores of cough,sputum,wheezing,and chest tightness in the observation group were significantly lower than those in the control group on 3,5 and 10 days after treatment(P < 0.05). The forced expiratory volume in the first second after treatment as a percentage of the predicted value(FEV1),the forced expiratory volume in the first second/forced vital capacity(FEV1/FVC),and the maximum expiratory flow(PEF)levels in the observation group were significantly higher than those in the control group(P < 0.05). After treatment,the ACT score of the observation group was significantly higher than that of the control group,and the levels of interleukin-6(IL-6)and interleukin-8(IL-8)were significantly lower than those of the control group(P < 0.05). Conclusion:The treatment with Qingre Pingchuan Decoction combined with western medicine for patients with bronchial asthma(heat syndrome)has good curative effect,has a significant effect on improving patients’ clinical symptoms and lung function,and can effectively reduce pro-inflammatory factors.更多还原