【摘要】 目的 探讨匹维溴铵联合谷维素治疗老年肠易激综合征的临床疗效。方法 将73例老年肠易激综合征患者随机分为试验组(n=37例)和对照组(n=36例)。试验组给予匹维溴铵治疗,3次/d,每次50 mg,另给予谷维素治疗,3次/d,每次30 mg。对照组只给予匹维溴铵治疗,3次/d,每次50 mg。两组均以30d为1个疗程,评估两组的临床治疗效果。结果 试验组和对照组的显效率分别62.3%和27.8%,两组比较差异有统计学意义(X~2=6.37,P<0.05)。试验组和对照组的总有效率分别89.2%和61.1%,两组比较差异亦有统计学意义(X~2=7.45,P<0.05)。两组均未出现明显不良反应,患者耐受性好。结论 匹维溴铵联合谷维素治疗老年肠易激综合征疗效明显,不良反应轻微,值得临床推广。更多还原

【Abstract】 Objective To investigate clinical efficacy of pinaverinm bromide combined with oryzanol in the treatment of older patients with irritable bowel syndrome. Methods Seventy-three older patients with irritable bowel syndrome( RomeⅡ diagnostic criteria for functional bowel disorders) were randomly divided into two groups: test group(n=37) and control group(n =36). Conrol group wore given pinaverium bromide treatment,three times a day,each time 50 mg. Test group were treated on the basis of another given oryzanol treatment three times a day, each time 30 mg. One cycle include 30 days,observed the clinical effect. Results The effective rate of the test group and control group were 64. 5% and 26.71%, respectively, there were significant differences between the two groups(X~2=6. 37.P<0. 05). The total effective rate of test group and control group were 64. 5% and 26. 7%, respectively, there were significant differences between the two groups(X~2= 7. 45,P< 0. 05). Conclusion Oryzanol plus pinaverium bromide in the treatment of older patients with irritable bowel syndrome has better clinical efficacy, mild adverse reactions, it is worthy of promotion.更多还原