【摘要】 安贝生坦为一种选择性内皮素A受体阻滞剂,临床用于治疗肺动脉高压。它能有效改善症状,且耐受性良好。与抗凝剂发生药物相互作用较少,肝功能损伤等不良反应发生率也较低。现对其药理作用、药动学、临床研究、安全性评价等方面做一综述。更多还原

【Abstract】 Ambrisentan is an orally active,potent and selective inhibitor of endothelin A receptor,and is used for the treatment of pulmonary arterial hypertension(PAH).Clinical studies indicate that ambrisentan significantly improves PAH.It is well tolerated with low rates of liver injuries,and less interacts with anticoagulants.In this paper,we reviewed the pharmacology,pharmacokinetics,clinical studies and safety evaluation of ambrisentan.更多还原