【摘要】 目的　了解新疆乌鲁木齐、阿勒泰地区不同民族围产母婴中人类疱疹病毒 8型 (HHV-8)感染情况。　方法　用间接免疫荧光法 (IFA) ,检测维吾尔族 (简称维族 )、哈萨克族 (简称哈族 )、汉族母亲血清和其婴儿脐血血清中 HHV- 8Ig G、Ig M抗体 ,共 40 6对。　结果　乌鲁木齐地区维族母婴HHV- 8Ig G阳性率均为 2 2 .9% (2 4/ 10 5 ) ,汉族母婴均为 5 .4% (8/ 149) (χ2 =17.1,P<0 .0 1)。阿勒泰地区哈族母婴 HHV- 8Ig G阳性率均为 2 6 .1% (2 7/ 10 3) ,汉族母婴为 8.1% (4/ 49) (χ2 =6 .7,P<0 .0 1)。维族及哈族阳性率明显高于当地汉族。HHV- 8Ig M抗体阳性率母亲为 0 .7% (3/ 40 6 )。　结论　新疆乌鲁木齐、阿勒泰地区不同民族围产母婴 HHV- 8感染率不同 ,母亲 HHV- 8活动感染率为0 .7%。HHV- 8Ig G阳性母亲的婴儿 Ig M阳性者 2例 ,宫内感染率为 3.17% (2 / 6 3)。HHV- 8Ig G抗体阳性的婴儿正在进一步随访。更多还原

【Abstract】 Objective To investigate the status of infection of human herpes virus type-8 (HHV-8) in the mother and their infants of Wulumuqi and Aletai region. Methods BCBL-1 cell line was used as antigen and 406 matched sera samples were collected from mothers and their infants (cord blood) of different nationalities (Uighur, Kazak and Han nationality) from Wulumuqi and Aletai regions of Xinjiang A.R, tested for HHV-8 IgG and IgM antibody by immunofluorescence assay. Results HHV-8 IgG antibody positive rate of mothers and their infants of Uighur nationality was 22.9%(24/105), Han was 5.4%(8/149) χ 2=17.1,P<0.01 in Wulumuqi region and Kazak nationality was 26.1%(27/103), Han nationality was 8.1%(4/49,χ 2=6.7,P<0.01) in Aletai region. The IgM positive rate of mothers was 0.7%(3/406) and their infants was 3.2%(2/63). Conclusions These data illustrate that the infective rate of HHV-8 in mothers and their infants in different nationality was different. Uighur was higher than Han in Wulumuqi region and Kazak was also higher than Han in Aletai region (P<0.05). The infants with HHV-8 IgG antibody positive need further follow-up.更多还原