【摘要】 用均匀设计法优化ＳＯＤ脂质体（Ｌ－ＳＯＤ）的制备工艺；制得包封率为６４．５２±３．３５％、粒径为０．０４～１．０μｍ的Ｌ－ＳＯＤ。并发现将此Ｌ－ＳＯＤ分散于１０ｍｍｏｌ／ＬＰＢＳ（含０．１５ｍｏｌ／ＬＮａＣｌ，ｐＨ７．４０）中比较稳定，在４℃避光密封贮存６个月，其ＳＯＤ活性存留率仍在７０％以上。更多还原

【Abstract】 Liposome-entrapped SOD(L-SOD) was prepared by reverse-phase evaporation, while the optimum experimental conditions were screened out by the uniform design method. The results showed that the extent of entrapment of the L-SOD was 64.52±3.35% and the particle size range was 0.04￣1.0μm.Stability test showed that the L-SOD was more stable in 10mmol/LPBS (with 0.15mol/L NaCl, pH 7.40) and the retained activity of SOD was more than 70% after 6 months stored at 4℃ in dark.更多还原