【摘要】 目的:介绍中国前瞻性城乡流行病学(PURE-China)研究的设计与方案,并对研究的合理性进行说明。方法:本研究来源于国际多中心队列前瞻性城乡流行病学(PURE)研究的中国现场。研究拟纳入40 000名中国社区人群,涉及全国12个省市的100余家社区,分布在我国东部、中部、西部地区的城市和农村。研究将从社区、家庭、个体这三个水平收集研究对象的人口统计学资料、既往疾病史、生活方式(吸烟、饮酒、体力活动及膳食)等信息,同时对研究对象进行基础的体格检查和生化检查,并测量心电图。研究随访将至少持续10年,以观察慢性非传染性疾病及其危险因素随城市化进程发生的变化。结果:PURE-China研究自2005年至2009年间进行受试者招募,共纳入研究对象46 285人,其中城市22 807人(49.3%),农村23 478人(50.7%)。东部地区入选24 807人,其中城市12 232人(49.3%),农村12 575人(50.7%);中部地区入选10 182人,其中城市5 058人(49.7%),农村5 124人(50.3%);西部地区入选11 296人,其中城市5517人(48.8%),农村5 699人(51.2%)。结论:本研究收集了中国城乡人群社会学因素与慢性非传染性疾病的重要信息,设计与方案合理,可以为我国慢病防治政策的制定提供参考依据,以缓和社会发展对健康带来的不利影响。更多还原

【Abstract】 Objective: To introduce the design and scheme of Chinese prospective urban and rural epidemiological(PURE-China) study and to explain the rationality of the research.Methods: The research was conducted by international multi-center PURE study in China site, which planned to recruit approximately 40,000 individuals from more than 100 communities of 12 provinces cross the country including urban and rural areas of eastern, central and western China. Demographic information, medical history, lifestyle behaviors(tobacco/alcohol use, physical activity and dietary profile) were collected from communities, households and individuals with the basic physical, biological and ECG examinations. The follow-up study has been planned for at least 10 years to observe the changes of chronic non-communicable diseases with the risk factors during urbanization process.Results: A total of 46,285 participants were enrolled from 2005 to 2009 those including 22,807(49.3%) in urban and 23,478(50.7%) in rural areas. There were 24,807 from eastern provinces including 12,232(49.3%) in urban and 12,575(50.7%) in rural areas; 10,182 from central provinces including 5058(49.7%) in urban and 5124(50.3%) in rural areas; 11,296 from western provinces including 5517(48.8%) in urban and 5,699(51.2%) in rural areas.Conclusion: The research has been collected important sociological and chronic non-communicable disease information in urban and rural areas of China. It provides the basis for preventing and controlling chronic disease during urbanization process.更多还原