【摘要】 目的调查湛江地区育龄女性人乳头状瘤病毒(human papillomavirus,HPV)感染率、感染亚型及年龄分布情况,为预防HPV感染和宫颈癌提供依据。方法回顾性分析2014年1月～2019年12月在广东医科大学附属医院妇产科门诊就诊的44 465例女性作为研究对象,通过DNA杂交技术检测宫颈脱落细胞的HPV基因亚型,并对HPV感染情况及基因亚型进行统计分析。结果 2014年感染HPV患者1 236例,感染率为20.38%,2015年感染HPV患者1 242例,感染率为18.97%;2016年感染HPV患者1 401例,感染率为19.22%;2017年感染HPV患者1 511例,感染率为18.59%;2018年感染HPV患者1 653例,感染率为20.19%;2019年感染HPV患者1 615例,感染率为19.57%;其中持续6年HPV高危型感染率前3位的分别为52、16、58亚型,年龄组分析显示,持续6年HPV总感染率最高的是≤20岁年龄组,其次是> 50岁年龄组。结论湛江地区女性HPV感染以HPV52、16、58亚型为主。应加强对年轻女性及50岁以上女性HPV感染的监测力度。更多还原

【Abstract】 Objective To investigate the infection rate, subtypes and age distribution of human papillomavirus(HPV) among women of childbearing age in Zhanjiang District,and to provide evidence for preventing HPV infection and cervical cancer. Methods Retrospective analysis was performed on 44,465 female patients treated in the department of obstetrics and gynecology of the affiliated hospital of Guangdong medical university from January 2014 to December 2019. The HPV gene subtypes of cervical exuded cells were detected by DNA hybridization, and the HPV infection status and gene subtypes were statistically analyzed. Results In 2014, there were 1,236 cases of HPV infection, with an infection rate of 20.38%, 1,242 cases of HPV infection in 2015, 18.97%, 1,401 cases of HPV infection in 2016, 19.22%, 1,511 cases of HPV infection in 2017, 18.59%, 1,653 cases of HPV infection in 2018, 20.19%, and 1,615 cases of HPV infection in 2019, with an infection rate of 19.57%. Among them, the top 3 infection rates of high-risk types of HPV for 6 years were subtypes 52, 16 and 58, respectively. Age group analysis showed that the highest infection rate for 6 years was ≤ 20 years old, followed by > 50 years old. Conclusion HPV infection in women in Zhanjiang was mainly caused by HPV52, 16 and 58 subtypes. Surveillance of HPV infection in young women(≤ 20 years old) and women over the age of 50 should be strengthened.更多还原