【摘要】 目的:探讨深圳地区健康体检人群饮食生活方式与颈动脉斑块形成的关系。方法:选取2019年1月至2019年6月深圳市人民医院的健康体检者1861例,收集所有受检者的人口学资料、生化检查、超声结果及饮食生活方式信息。根据颈动脉超声结果分为斑块组（n=427）和非斑块组（n=1434）。采用logistic多元回归模型分析与颈动脉斑块形成相关的因素。结果:该研究总体颈动脉斑块检出率为22.9 %。与非斑块组相比,斑块组的平均年龄更高,随着年龄的增长,颈动脉斑块发生率逐渐增高,且男性高于女性。斑块组的男性、吸烟、水果摄入不足(<100 g·d^-1)、高血压病史、糖尿病史及脂肪肝比例更高。logistic回归分析显示:高龄、男性、高糖化血红蛋白（HbA1c）、脂肪肝、高血压病史、吸烟、饮酒是颈动脉斑块的独立相关因素。结论:年龄增长是健康个体中颈动脉斑块发生的独立危险因素。对于有脂肪肝、高血压病史的健康体检者,有必要行颈动脉超声检查早期发现动脉斑块,尤其是吸烟者或男性,而降低HbA1c水平、戒烟、适量饮酒可能有助于预防动脉硬化的发生和发展。更多还原

【Abstract】 Objective To investigate the association of dietary and other lifestyle behaviors with carotid artery plaque formation among Shenzhen’s healthy population.Methods This cross-sectional study was performed on 1861 participants who underwent physical examination in Shenzhen People’s Hospital from January 2019 to June 2019.Details of demographics,biochemical test,the results of ultrasonography and lifestyle questionnaire were collected for all the participants.Subjects were categorized as "carotid plaque" group (n=427) or "non-carotid plaque" group (n=1434) according to their carotid artery ultrasonography.Multivariate logistic regression models were used to analysis the factors of diet and lifestyle related to carotid artery plaque.Results The overall prevalence of carotid plaque was 22.9 % in this study.The mean age in the "carotid plaque" group was much higher than those in the "non-carotid plaque" group.With the growth of age,the incidence of carotid artery plaque increases and the detection rate of carotid plaque in males was significantly higher than that in females.Age,rates of male,smoking,inadequate intake of fruit (< 100g per day),history of hypertension,history of diabetes and fatty liver in the "carotid plaque" group were significantly higher than those in the "non-carotid plaque" group.Multivariable logistic regression analyses revealed that age,male,high glycated hemoglobin,fatty liver,history of hypertension,smoking and alcohol consumption were independently associated with the formation of carotid artery plaque in healthy people.Conclusion The present study shows that increasing age is independent risk factor of carotid plaque in healthy individuals.We recommend that carotid ultrasonography should be performed in people with fatty liver and history of hypertension,especially in smokers or men.However,lower hemoglobin a1C level,smoking cessation and moderate drinking may help us to prevent the formation and development of atherosclerosis.更多还原