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2型糖尿病心血管并发症发病机制的研究进展
Progress on the pathogenesis of cardiovascular complications in patients with type 2 diabetes mellitus
【摘要】 2型糖尿病(T2DM)患者容易出现多种心血管并发症,如冠状动脉粥样硬化性心脏病、高血压、心力衰竭。导致T2DM患者并发心血管疾病的原因和机制错综复杂。有关的机制包括持续性高血糖、胰岛素抵抗、代谢紊乱、氧化应激、心肌纤维化、小血管病变和心脏自主神经病变。
【Abstract】 Patients with type 2 diabetes mellitus(T2DM) trend toward the multiple cardiovascular complications like coronary atherosclerotic heart disease, hypertension, heart failure. The causes and mechanisms leading to cardiovascular disease in patients with type 2 diabetes mellitus are complicated, which include persistent hyperglycemia, insulin resistance, metabolic disorders, oxidative stress, myocardial fibrosis, small vessel disease and cardiac autonomic neuropathy.
【关键词】 2型糖尿病;
心血管并发症;
胰岛素抵抗;
【Key words】 type 2 diabetes mellitus; cardiovascular complications; insulin resistance;
【Key words】 type 2 diabetes mellitus; cardiovascular complications; insulin resistance;
【基金】 中国医学科学院生物物理研究所科研基金(KJZD-EW-TZ-L05)
- 【文献出处】 基础医学与临床 ,Basic and Clinical Medicine , 编辑部邮箱 ,2022年05期
- 【分类号】R587.2;R54
- 【下载频次】275