【摘要】 目的 分析吲达帕胺与苯磺酸氨氯地平联合治疗高血压合并冠状动脉粥样硬化性心脏病（简称冠心病）的药学特点。方法 前瞻性随机选取2020年2月—2022年12月济宁市兖州区铁路医院收治的60例高血压合并冠心病患者为研究对象，经随机数表法分为两组，各30例。联合治疗组采用吲达帕胺联合苯磺酸氨氯地平治疗，单独治疗组采用苯磺酸氨氯地平治疗。对比两组心率、血压、血脂、颈动脉内膜中层厚度（Inteima-media Thickness, IMT）、心绞痛发作次数、持续时间、左室射血分数、生活质量和临床疗效。结果 联合治疗组的心率、血压、血脂水平、IMT均优于单独治疗组，差异有统计学意义（P均<0.05）。与单独治疗组相比，联合治疗组的心绞痛持续时间更短，心绞痛发作次数更少，左室射血分数和生活质量更高，差异有统计学意义（P均<0.05）。联合治疗组的总有效率（93.33%）高于单独治疗组（73.33%），差异有统计学意义（χ~2=4.320,P<0.05）。结论 吲达帕胺与苯磺酸氨氯地平联合治疗高血压合并冠心病的效果较苯磺酸氨氯地平单独治疗好。更多还原

【Abstract】 Objective To analyze the pharmacological characteristics of indapamide and amlodipine benzenesulfonate in the combined treatment of hypertension combined with coronary heart disease. Methods A total of 60 patients with hypertension combined with coronary heart disease admitted to Jining Yanzhou District Railway Hospital from February 2020 to December 2022 were prospectively and randomly selected as the study objects, and they were divided into two groups by random number table method, with 30 patients in each group. The combined treatment group was treated with indapamide combined with amlodipine benzenesulfonate, and the single treatment group was treated with amlodipine benzenesulfonate. Heart rate, blood pressure, blood lipids, carotid intima-media thickness(IMT), angina attack frequency, duration, left ventricular ejection fraction, life quality, and clinical effect were compared between the two groups. Results The heart rate, blood pressure, blood lipid level and IMT of combined treatment group were better than those of single treatment group, and the differences were statistically significant(all P<0.05). Compared with the single treatment group, the duration of angina pectoris in the combined treatment group was shorter, the frequency of angina pectoris was less, the left ventricular ejection fraction and life quality were higher, and the differences were statistically significant(all P<0.05). The total effective rate of the combined treatment group(93.33%) was higher than that of the single treatment group(73.33%), and the difference was statistically significant(χ~2=4.320, P<0.05). Conclusion The combination of indapamide and amlodipine benzenesulfonate is more effective than amlodipine benzenesulfonate alone in the treatment of hypertension combined with coronary artery disease.更多还原