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可生物降解医用镁基金属复合材料的研究进展

Research progress of biodegradable medical magnesium-based metal composites

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【作者】 杨黎方家栋兰海王晓东

【Author】 YANG Li;FANG Jia-dong;LAN Hai;WANG Xiao-dong;Zunyi Medical University;Affiliated Hospital of Chengdu University;

【通讯作者】 兰海;

【机构】 遵义医科大学成都大学附属医院

【摘要】 镁基金属复合材料目前广泛应用于生物医学领域,如骨科植入物等,现已成为第三代生物材料之一。与钛、不锈钢、钴铬等永久性植入物相比,镁具有生物可降解特点,因此镁基金属复合物是骨折内固定装置更好的选择,在骨折愈合后不需要二次手术将其移除。除此之外,镁能刺激新骨形成,具有抗菌特性,能降低因感染造成内固定失败的风险。基于诸多优点,人们对镁基金属可降解生物材料的开发越来越感兴趣。本文就镁基金属复合材料在生物医学领域的最新研究进展进行综述,对几种用于制备镁基金属复合材料的增强剂以及其加工技术进行全面描述,讨论增强体选择和制备工艺对镁基生物复合材料力学性能、腐蚀性能和生物性能的影响。

【Abstract】 Magnesium-based metal composites are currently widely used in biomedical fields, such as orthopedic implants, and have now become one of the third-generation biomaterials. Compared with permanent implants such as titanium, stainless steel, cobalt-chromium, magnesium is biodegradable. Magnesium-based metal composites are a better choice for internal fixation devices for fractures and do not require secondary surgical removal after fracture healing. In addition, magnesium stimulates new bone formation and has antibacterial properties, which can reduce the risk of internal fixation failure due to infection. There is growing interest in the development of magnesium-based metal-degradable biomaterials based on these advantages. This paper reviews the latest research progress of magnesium-based metal composites in the field of biomedicine, comprehensively describes several reinforcing agents used to prepare magnesium-based metal composites and their processing technologies, and discuss the effect of reinforcement materials selection and preparation process on the mechanical properties, corrosion properties and biological properties of magnesium-based biocomposites.

【基金】 四川省成都市科技局项目(编号:2021-YF05-00826-SN);四川省成都市卫健委项目(编号:2021116);四川省成都市金牛区医学会课题(编号:JNKY2021-07)
  • 【文献出处】 海南医学 ,Hainan Medical Journal , 编辑部邮箱 ,2023年06期
  • 【分类号】R318.08
  • 【下载频次】63
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