【摘要】 目的探讨血清全身免疫炎症指数(SII)、酪氨酸激酶2(DDR2)水平预测脑胶质瘤术后患者预后的临床价值。方法选取2015年3月至2017年10月在该院进行脑胶质瘤术的73例术后患者作为研究组,另选取同期54例健康者作为对照组,分析两组及研究组不同临床特点及预后情况的患者血清SII、DDR2水平差异。结果研究组患者血清SII、DDR2水平均高于对照组,差异均有统计学意义(P<0.05);世界卫生组织脑肿瘤分级Ⅲ～Ⅳ级患者血清SII、DDR2水平均明显高于Ⅰ～Ⅱ级患者,差异均有统计学意义(P<0.05);73例研究组患者随访3年,存活率为47.95%(35/73);生存组患者血清SII、DDR2水平均低于死亡组,差异均有统计学意义(P<0.05);血清SII、DDR2水平与预后情况均呈正相关(P<0.05)。结论血清SII、DDR2水平可预测脑胶质瘤术后患者预后状况,患者预后越差,血清SII、DDR2水平越高。更多还原

【Abstract】 Objective To investigate the clinical value of serum systemic immune inflammation index(SII) and discoidin domain receptor 2(DDR2) levels in predicting the prognosis of patients with glioma after operation.Methods From March 2015 to October 2017,a total of 73 cases of postoperative patients with glioma in the hospital were selected as the study group, and 54 cases of healthy people in the same period were selected as the control group.Serum levels of SII and DDR2 were analyzed between groups and the patients with different clinical characteristics and prognosis situations.Then serum SII and DDR2 levels were compared among patients with different clinical characteristics and prognosis status in study group.Results Serum SII and DDR2 levels in study group were higher than those in control group, and the differences were statistically significant(P<0.05).Serum SII and DDR2 levels of patients with WHO brain tumor grades of Ⅲ-Ⅳ were significantly higher than those of grade Ⅰ-Ⅱ,and the differences were statistically significant(P<0.05).73 patients in study group were followed up for 3 years, and the survival rate was 47.95%(35/73).Serum SII and DDR2 levels in survival group were lower than those in death group, and the differences were statistically significant(P<0.05).Serum levels of SII and DDR2 were positively correlated with prognosis(P<0.05).Conclusion Serum levels of SII and DDR2 have certain value in predicting the prognosis of patients with glioma after surgery and patient with higher serum SII and DDR2 levels have higher risk of poor prognosis.更多还原