【摘要】 本文探讨超声多模态评分、血流参数在不明原因复发性自然流产患者体内的变化及联合预测价值。选取不明原因复发性自然流产(URSA)早孕患者86例,根据孕12周内是否发生流产分为未流产组(62例)与流产组(24例),另选择同期正常早孕孕妇86例作为对照组。均行子宫内膜超声多模态评分、子宫动脉血流参数[搏动指数(PI)、阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D)]检查,发现超声多模态评分、PI、RI、S/D与URSA早孕患者β-HCG、孕酮及发生流产显著相关,联合预测URSA早孕患者发生流产的AUC为0.886,95%CI为0.806～0.965,敏感度为83.33%,特异度为83.87%,优于各指标单独预测。由此可见,URSA早孕患者的超声多模态评分和血流参数呈异常状态,联合预测流产的价值良好,能为临床及早采取干预措施提供有效信息。更多还原

【Abstract】 The purpose of this study was to investigate the changes of ultrasound multimodal scores and blood flow parameters in patients with unexplained recurrent spontaneous abortion and their combined predictive value.86 cases of early pregnancy patients with unexplained recurrent spontaneous abortion(URSA) were selected. According to whether miscarriage occurred within 12 weeks of gestation, they were divided into non-abortion group(62 cases) and miscarriage group(24 cases). And 86 pregnant women with normal early pregnancy during the same period were selected as the control group. Endometrial ultrasound multimodal score was detected, as well as uterine artery blood flow parameters including pulsatility index(PI), resistance index(RI), peak systolic velocity end diastolic velocity(S/D). It was found that ultrasound multimodal scores, PI, RI, S/D were significantly related to β-HCG, progesterone and miscarriage in early pregnancy patients of URSA. The AUC for combined predicting miscarriage in early pregnancy patients of URSA was 0.886,the 95%CI was 0.806 to 0.965.The sensitivity was 83.33%,and the specificity was 83.87%,which was better than the individual prediction of each index.It can be seen that ultrasound multimodal scores and blood flow parameters are abnormal in URSA patients.And the combined prediction for miscarriage has a good value,which can provide effective information for early clinical intervention.更多还原