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大鼠心脏不同部位α1肾上腺素受体亚型的分布
THE DISTRIBUTION OF DIFFERENT α1-ADRENOCEPTOR SUBTYPES IN RAT HEART
【摘要】 用放射配体结合实验研究大鼠心脏不同部位α1肾上腺素受体(α1受体)及其亚型的分布。结果表明,大鼠心脏左、右心房及心室中α1受体的密度基本一致;不同部位的α1受体均包含α1A与α1B两种亚型,左心房及心宝α1A亚型占全部α1受体的30%左右,α1B亚型占70%左右;而在右心房中α1A亚型的比例为14%左右,显著低于左心房与心室。说明大鼠心脏不同部位的α1受体分布相同,但其亚型分布具有显著的区别。
【Abstract】 e studied distribution of α1-adrenoceptor subtypes in rat heart by the methods of raioligand bin-ding assa y. The results showed that the densities of α1-adrenoceptors in left, right atria and ventricleswere the same as each other. All the α1-adrenoceptors in different parts of the heart contained twosubtypes(α1A and α1B). The α1B and α1B subytpes took 30%and 70% of all α1-adrenoceptor in leftatrium and ventricle respedtively, while in right atrium, α1A subtype took only 14% and 86%of α1Brespectively.
- 【文献出处】 北京医科大学学报 ,JOURNAL OF BEIJING MEDICAL UNIVERSITY , 编辑部邮箱 ,1994年04期
- 【分类号】R331.31
- 【被引频次】5
- 【下载频次】53