【摘要】 目的 探讨急性缺血性脑卒中静脉溶栓预后不良的相关危险因素。方法 通过回顾性收集2019年1月—2021年2月在国药同煤总医院住院诊断为急性缺血性脑卒中（AIS）并在4.5 h时间窗内给予rt-PA静脉溶栓治疗288例患者的一般资料及溶栓前化验结果，根据3个月MRS评分分为两组：<2分为预后良好组，2～6分为预后不良组。利用二元Logistic统计分析两组间的一般资料及化验结果。结果 观察期间入组患者288例，其中预后良好组207例，预后不良组81例；其中sICH者17例（5.90%），死亡5例（1.74%）; Logistic回归分析得出，患者脑梗死病史及溶栓前NIHSS评分在两组间差异有统计学意义（脑梗死P=0.030,OR=2.760;NIHSS评分P=0.000,OR=1.367）。结论 入院时NIHSS评分及既往脑梗死病史是急性缺血性脑卒中静脉溶栓预后不良的危险因素。更多还原

【Abstract】 Objective To investigate the risk factors for poor prognosis of acute ischemic stroke with intravenous thrombolysis. Methods From January 2019 to February 2021, patients who were hospitalized with acute ischemic stroke(AIS) in Tongmei General Hospital of Sinopharm were retrospectively collected and given rtpa intravenous thrombolysis within a 4.5 h time window. General information and pre-thrombotic laboratory results of 288 patients.According to the 3-month MRS score, the patients were divided into two groups: <2 points was divided into a good prognosis group, and 2-6 points was divided into a poor prognosis group. Used binary Logistic statistics to analyze the general data and laboratory results between the two groups. Results During the observation period, 288 patients were enrolled, including 207 patients with good prognosis and 81 patients with poor prognosis. Among them, 17 patients(5.9%) had sICH, and 5 patients(1.74%) died. The NIHSS score before thrombolysis was significantly different between the two groups(cerebral infarction P=0.030, OR =2.760; NIHSS score P=0.000, OR =1.367). Conclusion NIHSS score on admission and history of cerebral infarction are risk factors for poor prognosis of acute ischemic stroke with intravenous thrombolysis.更多还原