【摘要】 目的　探讨bcl xl蛋白和p5 3蛋白在上皮性卵巢癌中的表达及其相互关系。方法　应用免疫组织化学S P法检测10例正常卵巢、2 1例良性上皮性卵巢肿瘤、12例交界性肿瘤、72例恶性肿瘤组织中bcl xl蛋白和 p5 3蛋白表达情况 ,分析其表达与不同临床病理特征的关系。结果　bcl xl蛋白和 p5 3蛋白在正常卵巢和良性上皮性卵巢肿瘤中均为阴性表达 ,在交界性肿瘤中阳性表达率分别为 16 .6 7%和 8.33 % ,在恶性肿瘤中分别为 48.6 1%和 5 1.39% ,两者都与肿瘤的临床分期有关。bcl xl蛋白在Ⅲ、Ⅳ期恶性肿瘤中的阳性率分别为 5 4.0 5 %、71.43 % ,Ⅰ、Ⅱ期为 12 .5 0 %、45 .0 0 % ;p5 3蛋白在Ⅲ、Ⅳ期恶性肿瘤中的阳性率分别为5 9 .46 %、71.43 % ,明显高于Ⅰ、Ⅱ期的 2 5 .0 0 %、40 .0 0 %。两者均与肿瘤的病理学类型和病理学分级无关 ,未发现两者有相关性(P >0 .0 5 )。结论　bcl xl蛋白和 p5 3蛋白参与了卵巢肿瘤的发生发展过程 ,可作为卵巢恶性肿瘤的生物学标志物之一。更多还原

【Abstract】 Objective To investigate the expression of bcl-xl and p53 protein and their significance in epithelial ovarian neoplasm.Methods bcl-xl and p53 proteins were detected by immunohistochemical SP technique in 72 cases of ovarian cancer,12 cases of bordline tumor,21 cases of benign tumor and 10 cases of normal ovaries.The relationship between bcl-xl and p53 protein and clinical data of ovarian cancer was analyzed.Results Both bcl-xl and p53 proteins were negative in benign tumors and normal ovaries.Their positive rate was 16.67% and 8.33% in bordline tumor,and 48.61% and 51.39% in epithelial ovarian cancer,respectively.In epithelial ovarian cancer,the presence of bcl-xl and p53 protein was not related to histological types and differentiation.The positive rate of bcl-xl protein in stage Ⅰ、Ⅱ、Ⅲ、Ⅳ was 12.50%、45.00%、54.05%、71.43%,respectively(P<0.05).The same results were presented for p53 protein.Its positive rate in stage Ⅰ、Ⅱ、Ⅲ、Ⅳ was 25.00%、40.00%、59.46% and 71.43%,respectively(P< 0.05),both of them were in connection with clinical stage.There was not correlation between the expressions of the two proteins. Conclusion The results suggest that bcl-xl and p53 protein may be used as a valuable biomarker of epithelial ovarian cancer.更多还原